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Mitochondrial UPR through generations

Nature Cell Biology volume 23, pages 820–821 (2021)Cite this article

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Neuronal mitochondria perturbation elicits a mitochondrial unfolded protein response (UPRmt) in peripheral tissues cell non-autonomously, dependent on the Wnt signalling pathway. A study now reveals that a Wnt-mediated increase in maternally inherited mitochondria DNA is responsible for transgenerational UPRmt induced by neuronal mitochondria perturbation.

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Fig. 1: Transgenerational induction of UPRmt mediated by increased mtDNA levels.

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Authors and Affiliations

  1. Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA

    Mooncheol Park & Meng C. Wang

  2. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA

    Meng C. Wang

  3. Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX, USA

    Meng C. Wang

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  1. Mooncheol Park
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  2. Meng C. Wang
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Correspondence to Meng C. Wang.

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The authors declare no competing interests.

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Park, M., Wang, M.C. Mitochondrial UPR through generations. Nat Cell Biol 23, 820–821 (2021). https://doi.org/10.1038/s41556-021-00729-3

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