Synthesis of heterocyclic compounds containing quinoline scaffold gained significant attention of organic chemists due to their importance as a therapeutic agent in the pharmaceutical industry. Quinoline molecules exhibit extensive biological activities, a few of which are antiviral, anti-inflammatory antibacterial, antifungal, antiproliferative, anthelmintic and anticonvulsant. A variety of synthetic routes has been developed for construction compounds bearing the quinoline nucleus due to its broad spectrum of pharmacological activities. This review describes recent development in transition metal mediated synthetic protocols of these important heterocycles by the formation of quinoline rings or by substitution of quinoline rings, including both modified conventional name reactions and novel routes with highly functionalized quinoline products.

含有喹啉支架的杂环化合物的合成由于其作为制药工业治疗剂的重要性而受到有机化学家的极大关注。喹啉分子表现出广泛的生物活性，其中一些具有抗病毒、抗炎抗菌、抗真菌、抗增殖、驱虫和抗惊厥作用。由于其广泛的药理活性，已经开发了多种合成路线用于带有喹啉核的构建化合物。本综述描述了通过形成喹啉环或取代喹啉环来合成这些重要杂环的过渡金属介导的合成方案的最新进展，包括改进的常规名称反应和具有高度官能化喹啉产物的新路线。