Recent Advances in Transition Metal Mediated Synthetic Approaches to Quinoline Derivatives

Title:Recent Advances in Transition Metal Mediated Synthetic Approaches to Quinoline Derivatives

Volume: 18 Issue: 9

Author(s): Rukhsana Tabassum*, Muhammad Ashfaq and Hiroyuki Oku

Affiliation:

• Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, 36100,Pakistan

Keywords: Quinoline, quinoline derivatives, transition metal, catalyst, heterocyclic, synthesis.

Abstract: Synthesis of heterocyclic compounds containing quinoline scaffold gained significant attention of organic chemists due to their importance as a therapeutic agent in the pharmaceutical industry. Quinoline molecules exhibit extensive biological activities, a few of which are antiviral, anti-inflammatory antibacterial, antifungal, antiproliferative, anthelmintic and anticonvulsant. A variety of synthetic routes has been developed for construction compounds bearing the quinoline nucleus due to its broad spectrum of pharmacological activities. This review describes recent development in transition metal mediated synthetic protocols of these important heterocycles by the formation of quinoline rings or by substitution of quinoline rings, including both modified conventional name reactions and novel routes with highly functionalized quinoline products.

Cite this article as:

Tabassum Rukhsana *, Ashfaq Muhammad and Oku Hiroyuki , Recent Advances in Transition Metal Mediated Synthetic Approaches to Quinoline Derivatives, Letters in Organic Chemistry 2021; 18 (9) . https://dx.doi.org/10.2174/1570178617999201020215632