Multicomponent Reactions of Indoles with 1-Amino-5-aroyl-4-aryl-1HPyrimidin- 2-ones / -thiones: One-pot Three Component Synthesis of Novel Gramine Analogues,Letters in Organic Chemistry

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Multicomponent Reactions of Indoles with 1-Amino-5-aroyl-4-aryl-1HPyrimidin- 2-ones / -thiones: One-pot Three Component Synthesis of Novel Gramine Analogues
Letters in Organic Chemistry ( IF 0.7 ) Pub Date : 2021-08-31 , DOI: 10.2174/1570178617999201014165048
Hava Aydın ₁ , Elif Korkusuz ₂ , İsmail Yıldırım ₁

Affiliation

A one-pot three component synthesis of a series of new gramine derivatives was designed and achieved via reactions of indole or N-methylindole with aromatic aldehyde and heteroaryl amines at 80-110 °C for 10-24 hours in an oven under solvent- and catalyst-free conditions providing an efficient, convenient and green method for the syntheses of a series of indol-3-yl- and N-methylindol-3-yl-1-aminopyrimidin-2-ones/thiones. So, fourteen novel gramine derivatives were conveniently synthesized and characterized by elemental analyses, FT IR, ¹H and ¹³C NMR spectroscopic measurements.

中文翻译：

吲哚与 1-氨基-5-芳酰基-4-芳基-1HPpyrimidin-2-ones / -thiones 的多组分反应：新型禾本科类似物的一锅三组分合成

设计并通过吲哚或 N-甲基吲哚与芳香醛和杂芳胺在 80-110°C 的烘箱中在溶剂-和无催化剂条件为一系列 indol-3-yl- 和 N-methylindol-3-yl-1-aminopyrimidin-2-ones/thiones 的合成提供了一种高效、方便和绿色的方法。因此，通过元素分析、FT IR、¹ H 和¹³ C NMR 光谱测量，可以方便地合成和表征 14 种新型禾本科衍生物。

更新日期：2021-07-30

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