Multicomponent Reactions of Indoles with 1-Amino-5-aroyl-4-aryl-1HPyrimidin- 2-ones / -thiones: One-pot Three Component Synthesis of Novel Gramine Analogues

Title:Multicomponent Reactions of Indoles with 1-Amino-5-aroyl-4-aryl-1HPyrimidin- 2-ones / -thiones: One-pot Three Component Synthesis of Novel Gramine Analogues

Volume: 18 Issue: 9

Author(s): Hava Aydın, Elif Korkusuz and İsmail Yıldırım*

Affiliation:

• Department of Chemistry, Sciences Faculty, Erciyes University, 38039, Kayseri,Turkey

Keywords: Multicomponent reactions, Gramine, Indole, N-Methylindole, Pyrimidine amine, Aryl aldehyde.

Abstract: A one-pot three component synthesis of a series of new gramine derivatives was designed and achieved via reactions of indole or N-methylindole with aromatic aldehyde and heteroaryl amines at 80-110 °C for 10-24 hours in an oven under solvent- and catalyst-free conditions providing an efficient, convenient and green method for the syntheses of a series of indol-3-yl- and N-methylindol-3-yl-1-aminopyrimidin-2-ones/thiones. So, fourteen novel gramine derivatives were conveniently synthesized and characterized by elemental analyses, FT IR, ¹H and ¹³C NMR spectroscopic measurements.

Cite this article as:

Aydın Hava, Korkusuz Elif and Yıldırım İsmail*, Multicomponent Reactions of Indoles with 1-Amino-5-aroyl-4-aryl-1HPyrimidin- 2-ones / -thiones: One-pot Three Component Synthesis of Novel Gramine Analogues, Letters in Organic Chemistry 2021; 18 (9) . https://dx.doi.org/10.2174/1570178617999201014165048