This study developed a partially water-soluble carboxymethyl chitosan (PWCS) fibers by ethanol-water exhaustion method. Sodium carboxylate was successfully introduced into chitosan fibers, as evidenced by FTIR, which enhanced natural chitosan water solubility. SEM-EDS revealed that the sodium carboxylate groups presented in a gradient distribution from the exterior to the interior of the PWCS fibers, which leads to a controllable swelling performance. Moreover, the PWCS fibers had excellent antibacterial ability against S. aureus and E. coli bacteria comparing with origin CS fibers. The cytotoxicity assay (CCK-8) and fluorescence staining confirmed that all developed samples showed non-toxicity towards MRC-5 and exhibited a surprising promoting effect on cell proliferation, corroborating their biocompatibility. Besides, due to its excellent controllable water selling ability and protonated amine groups, the PWCS fibers possessed an efficient hemostatic performance. In conclusion, PWCS fibers could become a promising material in hemostatic and wound healing applications.

本研究通过乙醇-水耗尽法开发了一种部分水溶性的羧甲基壳聚糖 (PWCS) 纤维。FTIR 证明，羧酸钠被成功地引入壳聚糖纤维中，这增强了天然壳聚糖的水溶性。SEM-EDS 表明，羧酸钠基团从 PWCS 纤维的外部到内部呈梯度分布，这导致了可控的溶胀性能。此外，PWCS 纤维对金黄色葡萄球菌和大肠杆菌具有优异的抗菌能力细菌与原始 CS 纤维的比较。细胞毒性试验 (CCK-8) 和荧光染色证实，所有开发的样品均显示出对 MRC-5 的无毒性，并显示出对细胞增殖的惊人促进作用，证实了它们的生物相容性。此外，由于其优异的可控售水能力和质子化胺基团，PWCS纤维具有高效的止血性能。总之，PWCS 纤维可能成为止血和伤口愈合应用中的一种有前途的材料。