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Biocompatible Gradient Chitosan Fibers with Controllable Swelling and Antibacterial Properties

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Abstract

This study developed a partially water-soluble carboxymethyl chitosan (PWCS) fibers by ethanol-water exhaustion method. Sodium carboxylate was successfully introduced into chitosan fibers, as evidenced by FTIR, which enhanced natural chitosan water solubility. SEM-EDS revealed that the sodium carboxylate groups presented in a gradient distribution from the exterior to the interior of the PWCS fibers, which leads to a controllable swelling performance. Moreover, the PWCS fibers had excellent antibacterial ability against S. aureus and E. coli bacteria comparing with origin CS fibers. The cytotoxicity assay (CCK-8) and fluorescence staining confirmed that all developed samples showed non-toxicity towards MRC-5 and exhibited a surprising promoting effect on cell proliferation, corroborating their biocompatibility. Besides, due to its excellent controllable water selling ability and protonated amine groups, the PWCS fibers possessed an efficient hemostatic performance. In conclusion, PWCS fibers could become a promising material in hemostatic and wound healing applications.

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Acknowledgment

This work was partially supported by the China Postdoctoral Fund (NO. 2018M632618), National Key Research and Development Program of China (NO. 2017YFB0309805-02), National Natural Science Foundation of China (NO. 82001754) and National Key R&D Program of China (no. 2018YFA0900802).

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  1. These authors contribute equally to this work.

Authors and Affiliations

  1. Industrial Research Institute of Nonwovens and Technical Textiles, College of Textiles and Clothing, Qingdao University, Qingdao, 266071, China

    Shangpeng Liu, Yi Yu, Jiwei Li, Shaojuan Chen & Jianwei Ma

  2. Shandong Center for Engineered Nonwovens, Qingdao, 266071, China

    Shangpeng Liu & Jiwei Li

  3. National Manufacturing Innovation Center of Advanced Dyeing and Finishing Technology, Taian, 271000, China

    Shangpeng Liu & Jiwei Li

  4. Department of Biochemistry and Microbiology, Qingdao University Medical College, Qingdao, 266071, China

    Shuang Wang

  5. Department of Pathogenic Biology, Qingdao University Medical College, Qingdao, 266071, China

    Shasha Jiang

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  1. Shangpeng Liu
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  2. Yi Yu
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  4. Jiwei Li
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  7. Jianwei Ma
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Correspondence to Jiwei Li or Jianwei Ma.

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Liu, S., Yu, Y., Jiang, S. et al. Biocompatible Gradient Chitosan Fibers with Controllable Swelling and Antibacterial Properties. Fibers Polym 23, 1–9 (2022). https://doi.org/10.1007/s12221-021-3276-8

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  • DOI: https://doi.org/10.1007/s12221-021-3276-8

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