Microanalysis of Two Members of Oxicam Drugs by Quenching the Fluorescence of Newly Isolated Carbonaceous Materials From Incense Ash,Journal of Fluorescence

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Microanalysis of Two Members of Oxicam Drugs by Quenching the Fluorescence of Newly Isolated Carbonaceous Materials From Incense Ash
Journal of Fluorescence ( IF 2.6 ) Pub Date : 2021-07-27 , DOI: 10.1007/s10895-021-02774-5
Mohamed Rizk ₁ , Emad Ramzy ₁ , Nabil Abdel Ghany ₂ , Safaa Toubar ₁ , Marwa I Helmy ₁

Affiliation

For the first time ever, useful fluorescent (FL) carbonaceous materials (CMTS) were isolated from incense ash using facile procedure on two steps; dispersion of the CMTS in water followed by filtration. The CMTS were characterized using the following techniques; dynamic light scattering (DLS), transmission electron microscopy (TEM) and Fourier transform infrared (FT-IR) spectroscopy. The CMTS exhibit excitation wavelength dependent fluorescence emission, so it can be used as a FL probe. The FL probe was employed for sensing and quantitative determination of two members of oxicam family (tenoxicam (TEN) and meloxicam (MEL)) that belongs to non-steroidal anti-inflammatory drugs (NSAIDs). The method is based on the quenching of the FL intensity of the isolated CMTS by inner filter effect mechanism (IFE). The FL intensity decreases in linear relationship with increasing the concentrations of the two cited drugs within the range of 4.0 – 30.0 µg/mL with mean percentage recoveries of 100.04 ± 0.95 and 100.07 ± 1.06 with detection limits of 1.31 µg/mL and 1.06 µg/mL for TEN and MEL, respectively. Finally, the developed sensing system was validated as per ICH guidelines and it was proved to be accurate and precise and applied successfully for quantitative determination of the two cited drugs in their capsule dosage forms with excellent percentage recoveries reaching to 97.66 ± 0.39and 98.19 ± 1.12 for TEN and MEL, respectively.

Graphical Abstract

中文翻译：

通过淬灭香灰中新分离的碳质材料的荧光来微量分析奥昔康药物的两种成员

有史以来第一次，使用简单的两步程序从香灰中分离出有用的荧光（FL）碳质材料（CMTS）；将CMTS分散在水中，然后过滤。使用以下技术对 CMTS 进行表征；动态光散射 (DLS)、透射电子显微镜 (TEM) 和傅里叶变换红外 (FT-IR) 光谱。 CMTS 表现出与激发波长相关的荧光发射，因此它可以用作 FL 探针。 FL探针用于传感和定量测定属于非甾体抗炎药（NSAID）的昔康家族的两个成员（替诺昔康（TEN）和美洛昔康（MEL））。该方法基于通过内部过滤效应机制 (IFE) 对隔离 CMTS 的 FL 强度进行猝灭。在 4.0 – 30.0 µg/mL 范围内，FL 强度随两种药物浓度的增加呈线性关系下降，平均回收百分比为 100.04 ± 0.95 和 100.07 ± 1.06，检测限为 1.31 µg/mL 和 1.06 µg/分别为 10 和 MEL。最后，开发的传感系统根据 ICH 指南进行了验证，证明其准确和精确，并成功应用于两种胶囊剂型药物的定量测定，回收率达到 97.66 ± 0.39 和 98.19 ± 1.12分别为 10 和 MEL。

图解摘要

更新日期：2021-07-27

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