Topotecan (TPT), a potential antitumor agent for treating various cancers (lung, ovarian, etc.), is a water-soluble camptothecin derivative compound. It is utilized in hydrochloride salt to treat ovarian cancer, lung cancer, and other types of cancer. Herein, a stable and sensitive electrochemical sensor for topotecan hydrochloride detection based on a glassy carbon electrode fabricated by 2D-MoS₂/TiO₂ nanoparticles (GCE) was reported. First, 2D-MoS2 and TiO2 nanoparticles were synthesized to be utilized as the modifier of the glassy carbon electrode. 2D-MoS₂/TiO₂ was characterized by scanning electron microscope (SEM), x-ray diffraction (XRD) method, diffuse reflectance spectroscopy (DRS), chronoamperometry (CA) electrochemical impedance spectroscopy (EIS), Differential pulse voltammetry (DPV), and cyclic voltammetry (CV). The detection of TPT on the 2D-MoS₂/TiO₂/GCE was investigated by voltammetric approaches, and the analytical results were obtained. This work indicates that the oxidation reaction of TPT on 2D-MoS₂/TiO₂/GCE is occurred by almost two electrons and two proton reaction pathway, that is performed by just diffusion. The as-fabricated sensor can operate in the linear response range of 0.01 to 18.57 μM (R² = 0.9959), and limits of detection (LOD) of 9.8 nM for TPT. The results have proved that the proposed novel sensor can successfully determine TPT in the real samples with higher stability, sensitive reproducibility, and repeatability features.

拓扑替康 (TPT) 是一种水溶性喜树碱衍生化合物，是治疗各种癌症（肺癌、卵巢癌等）的潜在抗肿瘤剂。它在盐酸盐中用于治疗卵巢癌、肺癌和其他类型的癌症。在此，报道了一种基于由 2D-MoS ₂ /TiO ₂纳米颗粒 (GCE)制造的玻碳电极的用于盐酸拓扑替康检测的稳定且灵敏的电化学传感器。首先，合成了 2D-MoS2 和 TiO2 纳米颗粒，用作玻碳电极的改性剂。二维-MoS ₂ /TiO ₂通过扫描电子显微镜 (SEM)、X 射线衍射 (XRD) 法、漫反射光谱 (DRS)、计时电流法 (CA)、电化学阻抗谱 (EIS)、微分脉冲伏安法 (DPV) 和循环伏安法 (CV) 对其进行表征. 通过伏安法研究了TPT在2D-MoS ₂ /TiO ₂ /GCE上的检测，并获得了分析结果。这项工作表明TPT在2D-MoS ₂ /TiO ₂ /GCE上的氧化反应几乎是通过两个电子和两个质子的反应途径发生的，仅通过扩散进行。制造好的传感器可以在 0.01 至 18.57 μM (R ² = 0.9959)，TPT 的检测限 (LOD) 为 9.8 nM。结果证明，所提出的新型传感器可以成功地测定真实样品中的 TPT，具有更高的稳定性、灵敏的重现性和重复性特征。