During Parkinson disease progression, the accumulation of α-synuclein pathology is paralleled by changes in structural and functional connectivity in the brain. Two new studies pinpoint specific alterations in the brain connectome in the early stages of Parkinson disease and suggest future avenues of research to develop connectome-based biomarkers.

中文翻译：

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帕金森病连接组——来自新影像学研究的见解

在帕金森病进展期间，α-突触核蛋白病理学的积累与大脑结构和功能连接的变化并行。两项新研究指出了帕金森病早期大脑连接组的特定改变，并提出了未来的研究途径以开发基于连接组的生物标志物。