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PARKINSON DISEASE

The Parkinson disease connectome — insights from new imaging studies

Nature Reviews Neurology volume 17, pages 527–528 (2021)Cite this article

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During Parkinson disease progression, the accumulation of α-synuclein pathology is paralleled by changes in structural and functional connectivity in the brain. Two new studies pinpoint specific alterations in the brain connectome in the early stages of Parkinson disease and suggest future avenues of research to develop connectome-based biomarkers.

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References

  1. Poewe, W. et al. Parkinson disease. Nat. Rev. Dis. Primers 3, 17013 (2017).

    Article  Google Scholar 

  2. Bloem, B. R., Okun, M. S. & Klein, C. Parkinson’s disease. Lancet 397, 2284–2303 (2021).

    Article  CAS  Google Scholar 

  3. Yang, Y. et al. Alteration of brain structural connectivity in progression of Parkinson’s disease: a connectome-wide network analysis. Neuroimage Clin. 31, 102715 (2021).

    Article  Google Scholar 

  4. Hyder, R. et al. Functional connectivity of spoken language processing in early-stage Parkinson’s disease: an MEG study. Neuroimage Clin. https://doi.org/10.1016/j.nicl.2021.102718 (2021).

    Article  Google Scholar 

  5. Rosen, B. Q. & Halgren, E. A whole-cortex probabilistic diffusion tractography connectome. eNeuro https://doi.org/10.1523/ENEURO.0416-20.2020 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Tessitore, A., Cirillo, M. & Micco, R. D. Functional connectivity signatures of Parkinson’s disease. J. Parkinsons Dis. 9, 637–652 (2019).

    Article  Google Scholar 

  7. Zatorre, R. J., Fields, R. D. & Johansen-Berg, H. Plasticity in gray and white: neuroimaging changes in brain structure during learning. Nat. Neurosci. 15, 528–536 (2012).

    Article  CAS  Google Scholar 

  8. Tinaz, S. Functional connectome in Parkinson’s disease and parkinsonism. Curr. Neurol. Neurosci. Rep. 21, 24 (2021).

    Article  Google Scholar 

  9. Berg, D. et al. Prodromal Parkinson disease subtypes — key to understanding heterogeneity. Nat. Rev. Neurol. 17, 349–361 (2021).

    Article  Google Scholar 

  10. Johnson, M. E., Stecher, B., Labrie, V., Brundin, L. & Brundin, P. Triggers, facilitators, and aggravators: redefining Parkinson’s disease pathogenesis. Trends Neurosci. 42, 4–13 (2019).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Neurology, Medical University Innsbruck, Innsbruck, Austria

    Florian Krismer & Klaus Seppi

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  1. Florian Krismer
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  2. Klaus Seppi
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Correspondence to Klaus Seppi.

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The authors declare no competing interests.

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Krismer, F., Seppi, K. The Parkinson disease connectome — insights from new imaging studies. Nat Rev Neurol 17, 527–528 (2021). https://doi.org/10.1038/s41582-021-00543-3

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