Comorbidity with general medical conditions is common in individuals with eating disorders. Many previous studies do not evaluate types of eating disorder.

To provide relative and absolute risks of bidirectional associations between (a) anorexia nervosa, bulimia nervosa and eating disorders not otherwise specified and (b) 12 general medical conditions.

We included all people born in Denmark between 1977 and 2010. We collected information on eating disorders and considered the risk of subsequent medical conditions, using Cox proportional hazards regression. Absolute risks were calculated using competing risks survival analyses. We also considered risks for prior medical conditions and subsequent eating disorders.

An increased risk was seen for almost all disorder pairs (69 of 70). Hazard ratios for those with a prior eating disorder receiving a subsequent diagnosis of a medical condition ranged from 0.94 (95% CI 0.57−1.55) to 2.05 (95% CI 1.86−2.27). For those with a prior medical condition, hazard ratios for later eating disorders ranged from 1.35 (95% CI 1.26–1.45) to 1.98 (95% CI 1.71–2.28). Absolute risks for most later disorders were increased for persons with prior disorders, compared with reference groups.

This is the largest and most detailed examination of eating disorder–medical condition comorbidity. The findings indicate that medical condition comorbidity is increased among those with eating disorders and vice versa. Although there was some variation in comorbidity observed across eating disorder types, magnitudes of relative risks did not differ greatly.

在饮食失调的个体中，一般疾病的合并症很常见。之前的许多研究并未评估饮食失调的类型。

提供 (a) 神经性厌食症、神经性贪食症和未另行说明的饮食失调与 (b) 12 种一般医疗状况之间双向关联的相对和绝对风险。

我们纳入了 1977 年至 2010 年间出生在丹麦的所有人。我们收集了有关饮食失调的信息，并使用 Cox 比例风险回归考虑了随后出现医疗状况的风险。使用竞争风险生存分析计算绝对风险。我们还考虑了先前的医疗状况和随后的饮食失调的风险。

几乎所有疾病对（70 组中的 69 组）的风险均增加。对于既往患有饮食失调症的人，随后诊断出健康状况，其风险比范围为 0.94 (95% CI 0.57−1.55) 至 2.05 (95% CI 1.86−2.27)。对于既往有健康状况的人，后来出现饮食失调的风险比范围为 1.35 (95% CI 1.26–1.45) 至 1.98 (95% CI 1.71–2.28)。与参考组相比，患有既往疾病的人患大多数后来疾病的绝对风险增加。

这是对饮食失调-医疗状况合并症的最大、最详细的检查。研究结果表明，饮食失调患者的健康状况合并症增加，反之亦然。尽管不同饮食失调类型的合并症存在一些差异，但相对风险的大小差异并不大。