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A review on interplay between small RNAs and oxidative stress in cancer progression
Molecular and Cellular Biochemistry ( IF 3.5 ) Pub Date : 2021-07-22 , DOI: 10.1007/s11010-021-04228-9
Aparimita Das 1 , Harsha Ganesan 1 , Sushmitha Sriramulu 1 , Francesco Marotta 2 , N R Rajesh Kanna 3 , Antara Banerjee 1 , Fang He 4 , Asim K Duttaroy 5 , Surajit Pathak 1
Affiliation  

Oxidative stress has been known to be the underlying cause in many instances of cancer development. The new aspect of cancer genesis that has caught the attention of many researchers worldwide is its connection to non-coding RNAs (ncRNAs). ncRNAs may not be protein coding, but in light of the more recent discovery of their wide range of functions, the term ‘dark matter of the genome’ has been rendered inapplicable. There is an extensive mention of colon cancer as an example, where some of these ncRNAs and their manipulations have seen significant progress. As of now, the focus is on discovering a non-invasive, cost-effective method for diagnosis that is easier to monitor and can be conducted before visible symptoms indicate cancer in a patient, by which time it may already be too late. The concept of liquid biopsies has revolutionized recent diagnostic measures. It has been possible to detect circulating parts of the cancer genome or other biomarkers in the patients’ bodily fluids, resulting in the effective management of the disease. This has led these ncRNAs to be considered effective therapeutic targets and extrinsic modifications in several tumor types, proven to be effective as therapy. However, there is a vast scope for further understanding and pertinent application of our acquired knowledge and expanding it in enhancing the utilization of ncRNAs for a better prognosis, quicker diagnosis, and improved management of cancer. This review explores the prognosis of cancer and related mutations by scrutinizing small ncRNAs in the disease.



中文翻译:

癌症进展中小 RNA 与氧化应激相互作用的综述

众所周知,氧化应激是许多癌症发展的根本原因。引起全球许多研究人员关注的癌症发生的新方面是它与非编码 RNA (ncRNA) 的联系。ncRNA 可能不是蛋白质编码,但鉴于最近发现其广泛的功能,“基因组的暗物质”这一术语已不再适用。以结肠癌为例,其中一些 ncRNA 及其操作已经取得了重大进展。到目前为止,重点是发现一种非侵入性、具有成本效益的诊断方法,这种方法更易于监测,并且可以在患者出现明显症状表明癌症之前进行,到那时可能已经为时已晚。液体活检的概念彻底改变了最近的诊断措施。检测患者体液中癌症基因组的循环部分或其他生物标志物已经成为可能,从而有效地控制疾病。这导致这些 ncRNA 在几种肿瘤类型中被认为是有效的治疗靶点和外在修饰,被证明是有效的治疗方法。然而,对于我们获得的知识的进一步理解和相关应用以及将其扩展以提高对 ncRNA 的利用以实现更好的预后、更快的诊断和改进的癌症管理,仍有广阔的空间。本综述通过仔细检查疾病中的小 ncRNA 来探讨癌症的预后和相关突变。检测患者体液中癌症基因组的循环部分或其他生物标志物已经成为可能,从而有效地控制疾病。这导致这些 ncRNA 在几种肿瘤类型中被认为是有效的治疗靶点和外在修饰,被证明是有效的治疗方法。然而,对于我们获得的知识的进一步理解和相关应用以及将其扩展以提高对 ncRNA 的利用以实现更好的预后、更快的诊断和改进的癌症管理,仍有广阔的空间。本综述通过仔细检查疾病中的小 ncRNA 来探讨癌症的预后和相关突变。检测患者体液中癌症基因组的循环部分或其他生物标志物已经成为可能,从而有效地控制疾病。这导致这些 ncRNA 在几种肿瘤类型中被认为是有效的治疗靶点和外在修饰,被证明是有效的治疗方法。然而,对于我们获得的知识的进一步理解和相关应用以及将其扩展以提高对 ncRNA 的利用以实现更好的预后、更快的诊断和改进的癌症管理,仍有广阔的空间。本综述通过仔细检查疾病中的小 ncRNA 来探讨癌症的预后和相关突变。这导致这些 ncRNA 在几种肿瘤类型中被认为是有效的治疗靶点和外在修饰,被证明是有效的治疗方法。然而,对于我们获得的知识的进一步理解和相关应用以及将其扩展以提高对 ncRNA 的利用以实现更好的预后、更快的诊断和改进的癌症管理,仍有广阔的空间。本综述通过仔细检查疾病中的小 ncRNA 来探讨癌症的预后和相关突变。这导致这些 ncRNA 在几种肿瘤类型中被认为是有效的治疗靶点和外在修饰,被证明是有效的治疗方法。然而,对于我们获得的知识的进一步理解和相关应用以及将其扩展以提高对 ncRNA 的利用以实现更好的预后、更快的诊断和改进的癌症管理,仍有广阔的空间。本综述通过仔细检查疾病中的小 ncRNA 来探讨癌症的预后和相关突变。

更新日期:2021-09-28
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