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A review on interplay between small RNAs and oxidative stress in cancer progression

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Abstract

Oxidative stress has been known to be the underlying cause in many instances of cancer development. The new aspect of cancer genesis that has caught the attention of many researchers worldwide is its connection to non-coding RNAs (ncRNAs). ncRNAs may not be protein coding, but in light of the more recent discovery of their wide range of functions, the term ‘dark matter of the genome’ has been rendered inapplicable. There is an extensive mention of colon cancer as an example, where some of these ncRNAs and their manipulations have seen significant progress. As of now, the focus is on discovering a non-invasive, cost-effective method for diagnosis that is easier to monitor and can be conducted before visible symptoms indicate cancer in a patient, by which time it may already be too late. The concept of liquid biopsies has revolutionized recent diagnostic measures. It has been possible to detect circulating parts of the cancer genome or other biomarkers in the patients’ bodily fluids, resulting in the effective management of the disease. This has led these ncRNAs to be considered effective therapeutic targets and extrinsic modifications in several tumor types, proven to be effective as therapy. However, there is a vast scope for further understanding and pertinent application of our acquired knowledge and expanding it in enhancing the utilization of ncRNAs for a better prognosis, quicker diagnosis, and improved management of cancer. This review explores the prognosis of cancer and related mutations by scrutinizing small ncRNAs in the disease.

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Acknowledgements

We would like to thank Chettinad Academy of Research and Education for providing us the facilities to carry out the research work.

Funding

Not applicable.

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Authors and Affiliations

  1. Department of Medical Biotechnology, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Kelambakkam, Chennai, 603 103, India

    Aparimita Das, Harsha Ganesan, Sushmitha Sriramulu, Antara Banerjee & Surajit Pathak

  2. ReGenera R&D International for Aging Intervention and Vitality & Longevity Medical Science Commission, FEMTEC World Foundation, Milan, Italy

    Francesco Marotta

  3. Department of Pathology, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Kelambakkam, Chennai, 603 103, India

    N. R. Rajesh Kanna

  4. West China School of Public Health, Sichuan University, Chengdu, China

    Fang He

  5. Department of Nutrition, Institute of Basic Medical Science, Faculty of Medicine, University of Oslo, Oslo, Norway

    Asim K. Duttaroy

Authors
  1. Aparimita Das
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  2. Harsha Ganesan
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  3. Sushmitha Sriramulu
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  4. Francesco Marotta
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  5. N. R. Rajesh Kanna
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  6. Antara Banerjee
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  7. Fang He
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  8. Asim K. Duttaroy
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  9. Surajit Pathak
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Contributions

Writing (Original draft preparation)—AD and SP; Editing and Improving scientific outcomes—HG, SS, FM, RKN, FH, AKD, and AB. All authors revised and approved the content of the manuscript.

Corresponding author

Correspondence to Surajit Pathak.

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Das, A., Ganesan, H., Sriramulu, S. et al. A review on interplay between small RNAs and oxidative stress in cancer progression. Mol Cell Biochem 476, 4117–4131 (2021). https://doi.org/10.1007/s11010-021-04228-9

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  • DOI: https://doi.org/10.1007/s11010-021-04228-9

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