Rationale

Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor that has a particular role in regulating dopaminergic, serotonergic, and glutamatergic transmission. TAAR1 agonists have shown pro-cognitive activities. However, it remains largely unknown of the effects of TAAR1 agonists on memory performance.

Objectives

Here, by using the mice novel object recognition (NOR) test, we examined the effects of the selective TAAR1 partial agonist RO5263397 on recognition memory.

Results

We found that RO5263397 significantly enhanced the retrieval of short-term memory (STM; 20 min after training) both in male and female mice. RO5263397 promoted the retrieval of STM in the wild-type (WT) littermates but not TAAR1-KO mice, indicating that the effects of RO5263397 were dependent on TAAR1. Interestingly, compared to their WT litters, TAAR1-KO mice showed similar levels of STM, suggesting that genetic deletion of taar1 gene did not affect the STM retrieval. Furthermore, RO5263397 also promoted the retrieval of long-term NOR memory (24 h after training).

Conclusions

These results indicate that TAAR1 activation promotes NOR memory retrieval. Consistent with previous studies, our finding further suggests that TAAR1 agonists have pro-cognitive properties.

中文翻译：

---

选择性 TAAR1 部分激动剂 RO5263397 促进小鼠的新奇识别记忆

基本原理

微量胺相关受体 1 (TAAR1) 是一种 G 蛋白偶联受体，在调节多巴胺能、5-羟色胺能和谷氨酸能传递中具有特殊作用。TAAR1 激动剂已显示出促认知活性。然而，TAAR1 激动剂对记忆性能的影响在很大程度上仍是未知数。

目标

在这里，通过使用小鼠新物体识别 (NOR) 测试，我们检查了选择性 TAAR1 部分激动剂 RO5263397 对识别记忆的影响。

结果

我们发现 RO5263397 显着增强了雄性和雌性小鼠的短期记忆（STM；训练后 20 分钟）的恢复。RO5263397 促进了野生型 (WT) 同窝小鼠中 STM 的恢复，但不促进 TAAR1-KO 小鼠的恢复，表明 RO5263397 的作用依赖于 TAAR1。有趣的是，与它们的 WT 窝相比，TAAR1-KO 小鼠的 STM 水平相似，这表明 taar1 基因的遗传缺失不会影响 STM 的恢复。此外，RO5263397 还促进了长期 NOR 记忆（训练后 24 小时）的检索。

结论

这些结果表明 TAAR1 激活促进了 NOR 记忆检索。与之前的研究一致，我们的发现进一步表明 TAAR1 激动剂具有促认知特性。