Prostate cancer is largely unresponsive to immunotherapy. A new study finds elevated expression of the chemokine IL-8, or its mouse homolog Cxcl15, in prostate cancer after castration, which leads to the recruitment of immunosuppressive myeloid cells. Blocking tumor infiltration with these cells could improve the response to immune-checkpoint inhibition and androgen-deprivation therapy.

中文翻译：

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前列腺癌中 IL-8 球的背后

前列腺癌在很大程度上对免疫疗法没有反应。一项新研究发现，去势后前列腺癌中趋化因子 IL-8 或其小鼠同源物 Cxcl15 的表达升高，这导致免疫抑制性骨髓细胞的募集。用这些细胞阻断肿瘤浸润可以改善对免疫检查点抑制和雄激素剥夺疗法的反应。