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IMMUNOTHERAPY

Behind the IL-8 ball in prostate cancer

Nature Cancer volume 2, pages 775–776 (2021)Cite this article

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Prostate cancer is largely unresponsive to immunotherapy. A new study finds elevated expression of the chemokine IL-8, or its mouse homolog Cxcl15, in prostate cancer after castration, which leads to the recruitment of immunosuppressive myeloid cells. Blocking tumor infiltration with these cells could improve the response to immune-checkpoint inhibition and androgen-deprivation therapy.

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Fig. 1: Castration increases the recruitment of immunosuppressive myeloid cells to the prostate TME via IL-8.

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Authors and Affiliations

  1. Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Ravi A. Madan

  2. Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Claudia Palena

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  1. Ravi A. Madan
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  2. Claudia Palena
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Correspondence to Ravi A. Madan or Claudia Palena.

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The authors declare no competing interests.

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Madan, R.A., Palena, C. Behind the IL-8 ball in prostate cancer. Nat Cancer 2, 775–776 (2021). https://doi.org/10.1038/s43018-021-00235-3

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