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Recent Opportunities and Challenges in Selective C-H Functionalization of Methyl Azaarenes: A Highlight from 2010 to 2020 Studies
Current Organic Synthesis ( IF 1.7 ) Pub Date : 2021-11-30 , DOI: 10.2174/1566524021666210614141628
Fahimeh Abedinifar 1 , Mohammad Mahdavi 1 , Mehdi Asadi 1 , Haleh Hamedifar 2 , Samira Ansari 2 , Bagher Larijani 1
Affiliation  

Azaarenes are unique scaffolds that are frequently found in pharmaceuticals. Herein we have summarized the recent synthetic available methods in C–H functionalization of methylazaarenes from 2010 to 2020. Multiple approaches involving halogenation, alkylation via different methods, alkenylation, oxidative functionalization, and cyclization of the methylazaarenes will be discussed in this review.



中文翻译:

甲基氮杂芳烃选择性 CH 官能化的近期机遇和挑战:2010 年至 2020 年研究的亮点

氮杂芳烃是药物中常见的独特支架。在此,我们总结了 2010 年至 2020 年甲基氮杂芳烃 C-H 官能化的最新合成可用方法。本文将讨论甲基氮杂芳烃的卤化、不同方法的烷基化、烯基化、氧化官能化和环化等多种方法。

更新日期:2021-12-03
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