Abstract
Azaarenes are unique scaffolds that are frequently found in pharmaceuticals. Herein we have summarized the recent synthetic available methods in C–H functionalization of methylazaarenes from 2010 to 2020. Multiple approaches involving halogenation, alkylation via different methods, alkenylation, oxidative functionalization, and cyclization of the methylazaarenes will be discussed in this review.
Keywords: Azaarenes, pharmaceutical, C-H functionalization, alkenylation, oxidative, cyclization.
Current Organic Synthesis
Title:Recent Opportunities and Challenges in Selective C-H Functionalization of Methyl Azaarenes: A Highlight from 2010 to 2020 Studies
Volume: 18 Issue: 8
Author(s): Fahimeh Abedinifar, Mohammad Mahdavi*, Mehdi Asadi , Haleh Hamedifar , Samira Ansari*Bagher Larijani
Affiliation:
- Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran 14176,Iran
- CinnaGen Medical Biotechnology Research Center, Alborz University of Medical Sciences, Karaj,Iran
Keywords: Azaarenes, pharmaceutical, C-H functionalization, alkenylation, oxidative, cyclization.
Abstract: Azaarenes are unique scaffolds that are frequently found in pharmaceuticals. Herein we have summarized the recent synthetic available methods in C–H functionalization of methylazaarenes from 2010 to 2020. Multiple approaches involving halogenation, alkylation via different methods, alkenylation, oxidative functionalization, and cyclization of the methylazaarenes will be discussed in this review.
Export Options
About this article
Cite this article as:
Abedinifar Fahimeh , Mahdavi Mohammad *, Asadi Mehdi, Hamedifar Haleh , Ansari Samira *, Larijani Bagher , Recent Opportunities and Challenges in Selective C-H Functionalization of Methyl Azaarenes: A Highlight from 2010 to 2020 Studies, Current Organic Synthesis 2021; 18 (8) . https://dx.doi.org/10.2174/1566524021666210614141628
DOI https://dx.doi.org/10.2174/1566524021666210614141628 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
Call for Papers in Thematic Issues
Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis
Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
Photoswitches for Molecular Recognition
This Special Issue would cover the hot topics on synthesis and chemical and photophysical characterization of new photoswitchable derivatives and their applications on molecular recognition of metabolites and biological active compounds, both in physiological medium and in living cells. Photoswitches are compounds that can change their conformation or properties in ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Appreciating the Balance between Classical Interleukin (IL)-6 Receptor Signaling and IL-6 Trans-Signaling: Implications for Arthritis Progression
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Editorial
Current Drug Therapy Fused Aryl-Phenazines: Scaffold for the Development of Bioactive Molecules
Current Drug Targets Innovative Treatment Approach for Cancer-Related Cachexia
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry The Role of Universal Stress Proteins in Bacterial Infections
Current Medicinal Chemistry Nanochemistry-Based Immunotherapy for HIV-1
Current Medicinal Chemistry Editorial (Thematic Issue: Iron Chelation and Drug Resistance in Cancer and Tuberculosis)
Current Pharmaceutical Biotechnology Synthesis and Biological Evaluation of Novel N' (4-aryloxybenzylidene)- 1H-Benzimidazole-2 Carbohydrazide Derivatives as Anti-Tubercular Agents
Combinatorial Chemistry & High Throughput Screening Development of New Antituberculous Drugs: Strategies for New Drug Targets and Drug Delivery
Drug Design Reviews - Online (Discontinued) Synthesis and Molecular Modeling Studies of Novel 2,4-Disubstituted-1, 5-Diphenyl-1-H-Imidazole Derivatives as Potential Anti-Tubercular Agents
Current Bioactive Compounds Natural T Cell Immunity to Intracellular Pathogens and Nonpeptidic Immunoregulatory Drugs
Current Molecular Medicine Synthesis and Biological Evaluation of N-(Alkyl)-2-Thiophen-2-Ylacetamides Series As A New Class of Antitubercular Agents
Letters in Drug Design & Discovery Current Status of Computer-Aided Drug Design for Type 2 Diabetes
Current Computer-Aided Drug Design Drug Delivery Systems: A Few Examples of Applications, Drug Cargoes, and Administration Routes
Current Pharmaceutical Design Adrenomedullin as a Potential Therapeutic Agent for Inflammatory Bowel Disease
Current Protein & Peptide Science Meet Our Editorial Board Member
Combinatorial Chemistry & High Throughput Screening A Developmental Approach to Drug-induced Liver Injury in Newborns and Children
Current Medicinal Chemistry Can't Always Get What you Want? Try an Indirect Route you Just Might Get What you Need: A Study on Access to Genetic Data by Canadian Life Insurers
Current Pharmacogenomics and Personalized Medicine Design and Synthesis of Novel Oxadiazole and Diphenyl Ether Hydrazone Derivatives of Coumarin as Potential Antibacterial Agents
Current Bioactive Compounds Approaches to Target Profiling of Natural Products
Current Medicinal Chemistry