There has been an increase in the incidence of chronic neurodegenerative disorders of the central nervous system, including Alzheimer's and Parkinson's diseases, over the recent years mostly due to the rise in the number of elderly individuals. In addition, various neurodegenerative disorders are related to imbalances in the CXCL12/CXCR4/ACKR3 response axis. Notably, the CXC Chemokine Ligand 12 (CXCL12) is essential for the development of the central nervous system. Moreover, the expression and distribution of CXCL12 and its receptors are associated with the aggravation or alleviation of symptoms of neurodegenerative disorders. Therefore, the current review sought to highlight the specific functions of CXCL12 and its receptors in various neurodegenerative disorders, in order to provide new insights for future research.

中文翻译：

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中枢神经系统慢性神经退行性疾病中的 CXCL12/CXCR4/ACKR3 反应轴：治疗靶点和生物标志物。


近年来，中枢神经系统慢性神经退行性疾病（包括阿尔茨海默病和帕金森病）的发病率有所增加，这主要是由于老年人数量的增加。此外，各种神经退行性疾病都与CXCL12/CXCR4/ACKR3反应轴的失衡有关。值得注意的是，CXC 趋化因子配体 12 (CXCL12) 对于中枢神经系统的发育至关重要。此外，CXCL12及其受体的表达和分布与神经退行性疾病症状的加重或减轻有关。因此，本综述旨在强调CXCL12及其受体在各种神经退行性疾病中的具体功能，以期为未来的研究提供新的见解。