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The CXCL12/CXCR4/ACKR3 Response Axis in Chronic Neurodegenerative Disorders of the Central Nervous System: Therapeutic Target and Biomarker

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Abstract

There has been an increase in the incidence of chronic neurodegenerative disorders of the central nervous system, including Alzheimer’s and Parkinson’s diseases, over the recent years mostly due to the rise in the number of elderly individuals. In addition, various neurodegenerative disorders are related to imbalances in the CXCL12/CXCR4/ACKR3 response axis. Notably, the CXC Chemokine Ligand 12 (CXCL12) is essential for the development of the central nervous system. Moreover, the expression and distribution of CXCL12 and its receptors are associated with the aggravation or alleviation of symptoms of neurodegenerative disorders. Therefore, the current review sought to highlight the specific functions of CXCL12 and its receptors in various neurodegenerative disorders, in order to provide new insights for future research.

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Data Availability

All data generated or analyzed during this study are included in this published article.

Abbreviations

PSP:

Progressive supranuclear palsy

PD:

Parkinson disease

FTD:

Frontotemporal dementia

AD:

Alzheimer’s disease

MS:

Multiple sclerosis

SDF-1:

Stromal cell-derived factor 1

CXCL12:

CXC chemokine ligand 12

CXCR4:

CXC chemokine receptor 4

ACKR3:

Atypical chemokine receptor 3

CXCR7:

CXC chemokine receptor 7

GAG:

Glycosaminoglycan

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Funding

This research was supported by the Natural Science Foundation of Liaoning Province, China (2019-ZD-0772) and the National Natural Science Foundation of China (Grant Nos. 81471809; 81971639).

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Authors and Affiliations

  1. Department of Ultrasound, First Affiliated Hospital of China Medical University, Liaoning Province, Shenyang City, 110001, People’s Republic of China

    Yudie Yan & Zhen Zhang

  2. Jinzhou Medical University, Liaoning Province, Jinzhou City, People’s Republic of China

    Jingtong Su

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  1. Yudie Yan
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  2. Jingtong Su
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  3. Zhen Zhang
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YY conceived the study and wrote the manuscript; JS contributed to manuscript preparation and data analysis and interpretation; ZZ revised the work critically for important intellectual content and approved the version to be published.

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Correspondence to Zhen Zhang.

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Yan, Y., Su, J. & Zhang, Z. The CXCL12/CXCR4/ACKR3 Response Axis in Chronic Neurodegenerative Disorders of the Central Nervous System: Therapeutic Target and Biomarker. Cell Mol Neurobiol 42, 2147–2156 (2022). https://doi.org/10.1007/s10571-021-01115-1

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