Many widely used chemicals result in ubiquitous human exposure from multiple sources, including diet. Legislation mainly deals with the toxicological evaluation of single substances owing to a methodological and conceptual lack of alternatives, and does so within defined silos subject to over 40 distinct regulations in the EU alone. Furthermore, much of the research and many of the initiatives concerned with the assessment and evaluation of chemical mixtures and their potential effects on human health rely on retrospective analysis. Here we propose an approach for the prospective identification, assessment and regulation of mixtures relevant to human health. We address two distinct aspects of toxicology—which chemicals actually do occur together, and how potential mixture-related health hazards can be predicted—with an adapted concept of the exposome and large-scale hazard screens. The proactive use of the likelihood of co-exposure, together with the new approach of methods-based testing, may be a timely and feasible way of identifying those substances and mixtures where hazards may have been overlooked and regulatory action is needed. Ideally, we would generate co-exposure patterns for specific consumer groups, depending on lifestyle and dietary habits, to assess the specific risk of identified mixtures.

许多广泛使用的化学品导致人类从多种来源（包括饮食）无处不在地接触到这些化学品。由于缺乏替代品的方法和概念，立法主要涉及单一物质的毒理学评估，并且仅在欧盟就受制于 40 多个不同法规的规定孤岛内进行。此外，许多与评估和评估化学混合物及其对人类健康的潜在影响有关的研究和许多举措都依赖于回顾性分析。在这里，我们提出了一种对与人类健康相关的混合物进行前瞻性识别、评估和监管的方法。我们解决了毒理学的两个不同方面——哪些化学物质确实同时存在，以及如何预测与混合物相关的潜在健康危害——利用暴露组和大规模危害筛查的适应性概念。主动使用共同暴露的可能性，以及基于方法的测试新方法，可能是一种及时可行的方法，可以识别那些可能忽视了危害并需要采取监管行动的物质和混合物。理想情况下，我们会根据生活方式和饮食习惯为特定消费者群体生成共同暴露模式，以评估已识别混合物的特定风险。可能是一种及时可行的方法，可以识别那些危险可能被忽视并且需要采取管制行动的物质和混合物。理想情况下，我们会根据生活方式和饮食习惯为特定消费者群体生成共同暴露模式，以评估已识别混合物的特定风险。可能是一种及时可行的方法，可以识别那些危险可能被忽视并且需要采取管制行动的物质和混合物。理想情况下，我们会根据生活方式和饮食习惯为特定消费者群体生成共同暴露模式，以评估已识别混合物的特定风险。