In the inpatient setting, antibiotics are generally administered via bedside pumps with multiple daily dosing. Utilisation of a continuous antibiotic infusion (CAI) instead might have patient and nursing satisfaction, workflow efficiencies and infection control benefits. We aimed to study the utilisation of CAI in the inpatient setting for routine antibiotic administration. Patients receiving a peripherally inserted central venous catheter (PICC) for antibiotic administration were screened for the study. The patients were randomised to either (1) standard pump and intermittent antibiotic administration (IAA) or (2) CAI via an ambulatory pump. An accelerometer placed on the ankle was used to assess patient activity. Nursing and patient satisfaction surveys were also carried out. Forty patients met the study criteria for enrolment with 21 patients being enrolled in the CAI arm of the study. One hundred and five days of accelerometer recordings were available for analysis. The geometric mean activity was 45 min/day in the standard arm and 64 min/day in the CAI arm. This represented a 42% (95% CI: −14 to 133%, p = 0.16) difference in activity between the two groups. Nursing staff reported that they spent less time throughout their shift attending the antibiotic line or pump in patients who were in the CAI arm of the study (p < 0.001). In addition, patients in this arm of the study were more likely to recommend this method of administration of antibiotics to a family member (p =0.0001). The MOBILISE study showed nursing and patient satisfaction when CAI were utilised in the inpatient setting. A statistically non-significant difference in mobility was seen. The trial was registered (28/03/2018) with the Australia New Zealand Clinical Trials Registry (ACTRN12618000452291).

在住院环境中，抗生素通常通过床边泵给药，每日多次给药。相反，使用连续抗生素输注 (CAI) 可能会提高患者和护理人员的满意度、工作流程效率和感染控制优势。我们旨在研究 CAI 在住院患者常规抗生素给药中的应用。该研究筛选了接受外周插入中心静脉导管 (PICC) 以进行抗生素给药的患者。患者被随机分配到 (1) 标准泵和间歇性抗生素给药 (IAA) 或 (2) 通过动态泵的 CAI。放置在脚踝上的加速度计用于评估患者的活动。还进行了护理和患者满意度调查。40 名患者符合纳入研究标准，其中 21 名患者被纳入研究的 CAI 组。一百零五天的加速度计记录可用于分析。标准组的几何平均活动为 45 分钟/天，CAI 组为 64 分钟/天。这代表了两组之间活动的 42%（95% CI：-14% 至 133%，p = 0.16）差异。护理人员报告说，他们在整个轮班中花费的时间更少，用于研究 CAI 组的患者的抗生素生产线或泵（p < 0.001）。此外，该研究组的患者更有可能向家庭成员推荐这种抗生素给药方法（p = 0.0001）。MOBILIZE 研究显示了在住院环境中使用 CAI 时的护理和患者满意度。观察到流动性的统计上非显着差异。该试验已在澳大利亚新西兰临床试验注册中心 (ACTRN12618000452291) 注册 (28/03/2018)。