Influence of the 2H/1H Isotope Composition of the Water Environment on the Probability of Denaturation Bubble Formation in a DNA Molecule,Physics of Wave Phenomena

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Influence of the 2H/1H Isotope Composition of the Water Environment on the Probability of Denaturation Bubble Formation in a DNA Molecule
Physics of Wave Phenomena ( IF 1.4 ) Pub Date : 2021-07-13 , DOI: 10.3103/s1541308x2102014x
A. A. Svidlov _{1,

2} , M. I. Drobotenko ₁ , A. A. Basov _{1,

3} , A. A. Elkina _{1,

2} , M. G. Baryshev _{1,

2,

4} , S. S. Dzhimak _{1,

2} , V. V. Malyshko _{2,

3} , E. O. Gerasimenko ₄

Affiliation

Abstract

The role of single protium–deuterium exchanges in formation of open-state bubbles is investigated using mathematical modeling methods. It is shown that the probability for formation of bubbles with a certain length (12 to 27 nucleotides) depends on localization of the deuterium atom in the DNA molecule and may be appreciably different from the general probability for occurrence of open states.

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