Abstract
The role of single protium–deuterium exchanges in formation of open-state bubbles is investigated using mathematical modeling methods. It is shown that the probability for formation of bubbles with a certain length (12 to 27 nucleotides) depends on localization of the deuterium atom in the DNA molecule and may be appreciably different from the general probability for occurrence of open states.
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The work was supported by the Russian Foundation for Basic Research, project no. 20-41-235002, and by the Krasnodar krai administration.
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Translated by M. Potapov
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Svidlov, A.A., Drobotenko, M.I., Basov, A.A. et al. Influence of the 2H/1H Isotope Composition of the Water Environment on the Probability of Denaturation Bubble Formation in a DNA Molecule. Phys. Wave Phen. 29, 180–185 (2021). https://doi.org/10.3103/S1541308X2102014X
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DOI: https://doi.org/10.3103/S1541308X2102014X