Abstract

The results of identifying the vaccinia virus with the use of nanowire biosensors manufactured on the basis of silicon-on-insulator (SOI) films were presented. In our experiments, the vaccinia virus, the LIVP strain from the collection of the State Research Center of Virology and Biotechnology VECTOR of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, and the rabbit blood serum containing specific polyclonal antibodies to the vaccinia virus were used. As shown by our studies, the polyvalent blood serum was electrically neutral at the sensor surface–viral suspension phase interface, the vaccinia virus was positively charged, and polyvalent blood serum–vaccinia virus vaccine complexes had a negative effective charge.

中文翻译：

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使用纳米线绝缘体硅生物传感器识别痘苗病毒

摘要

介绍了使用基于绝缘体上硅 (SOI) 薄膜制造的纳米线生物传感器识别痘苗病毒的结果。在我们的实验中，牛痘病毒、来自联邦消费者权益保护和人类福祉监督服务局病毒学和生物技术研究中心 VECTOR 的 LIVP 毒株，以及含有牛痘特异性多克隆抗体的兔血清病毒被使用。正如我们的研究表明，多价血清在传感器表面-病毒悬浮相界面处呈电中性，痘苗病毒带正电荷，多价血清-牛痘病毒疫苗复合物带负有效电荷。