Topiramate (TOP) drug is classified as one of the most commonly used human drugs for anticonvulsants and antiepileptic, so its rapid detection and monitoring is of great importance. In this work, new potentiometric (MIP/PVC/GCE) and voltammetric (MIP/GO/GCE) sensors for the selective and sensitive determination of TOP were fabricated based on the molecularly imprinted polymer (MIP) approach. The MIP was synthesized by the polymerization of acrylamide and methacrylic acid as monomers, in the presence of TOP as a template and ethylene glycol dimethacrylate as a cross-linker. The obtained products were characterized by FT-IR, SEM, BET, and EDX. The MIP was embedded in a plasticized polyvinyl chloride membrane and used as a potentiometric sensor for sensing TOP. Alternatively, the synthesized MIP and graphene oxide (GO) were deposited layer-by-layer on the surface of GCE to construct a voltammetric sensor for studying the electrochemical behavior of the drug. Under optimized conditions, both electrochemical sensors showed excellent linear relationships between the concentration of TOP and the response signals of MIP/GO/GCE or MIP/PVC/GCE sensors in the 2.7 × 10⁻¹⁰ to 4.9 × 10⁻³ M and 1 × 10⁻⁹ to 3.4 × 10⁻³ M ranges, respectively. Also, both sensors have good reproducibility and high stability for up to 15 days for a voltammetric sensor and 28 days for a potentiometric sensor. The utility of these sensors was checked for TOP analysis in different real samples with good recovery (92.8 – 99%).

托吡酯（TOP）药物被列为人类最常用的抗惊厥药和抗癫痫药之一，因此其快速检测和监测具有重要意义。在这项工作中，基于分子印迹聚合物 (MIP) 方法制造了用于选择性和灵敏测定 TOP 的新型电位 (MIP/PVC/GCE) 和伏安 (MIP/GO/GCE) 传感器。MIP是通过丙烯酰胺和甲基丙烯酸作为单体，在TOP作为模板和乙二醇二甲基丙烯酸酯作为交联剂存在下聚合合成的。所得产物通过 FT-IR、SEM、BET 和 EDX 进行表征。MIP 嵌入增塑聚氯乙烯膜中，用作感应 TOP 的电位传感器。或者，合成的 MIP 和氧化石墨烯 (GO) 逐层沉积在 GCE 表面，以构建伏安传感器，用于研究药物的电化学行为。在优化条件下，两种电化学传感器在 2.7 × 10 的 TOP 浓度与 MIP/GO/GCE 或 MIP/PVC/GCE 传感器的响应信号之间显示出极好的线性关系。^-10至4.9 × 10 ^-3 M 和1 × 10 ^-9至3.4 × 10 ^-3 M 的范围分别。此外，两种传感器都具有良好的重现性和高稳定性，伏安传感器最长可达 15 天，电位传感器最长可达 28 天。这些传感器的效用在不同的实际样品中进行了 TOP 分析，回收率良好 (92.8 – 99%)。