Ovarian cancer is one of the main causes of women’s mortality worldwide. A variety of biological mechanisms are involved in ovarian cancer pathogenesis, including epigenetic alterations, mutations (especially in tumor suppressor genes), upregulated oncogenes, decreased apoptotic pathways, and dysregulation of other signaling pathways. Surgery and chemotherapy are two common approaches for treating ovarian cancer. Chemoresistance to common therapeutic drugs results in a lack of significant improvements in ovarian cancer therapy. In this regard, finding and developing new therapeutic platforms are required. Utilizing medicinal plants has emerged as a new horizon in the treatment of various cancers, such as ovarian cancer. Berberine is a yellow extract obtained from different plants and shows various antitumor activities. Also, clinical studies indicated that berberine is a safe and nontoxic compound. Herein, we reviewed the role of berberine in different aspects of ovarian cancers, such as apoptosis.

卵巢癌是全球女性死亡的主要原因之一。卵巢癌发病机制涉及多种生物学机制，包括表观遗传改变、突变（尤其是抑癌基因）、癌基因上调、凋亡通路减少和其他信号通路失调。手术和化疗是治疗卵巢癌的两种常用方法。对常见治疗药物的化学抗性导致卵巢癌治疗缺乏显着改善。在这方面，需要寻找和开发新的治疗平台。利用药用植物已成为治疗各种癌症（如卵巢癌）的新领域。小檗碱是一种从不同植物中提取的黄色提取物，具有多种抗肿瘤活性。还，临床研究表明，小檗碱是一种安全无毒的化合物。在此，我们回顾了小檗碱在卵巢癌不同方面的作用，例如细胞凋亡。