Abstract

We proposed a method for the rapid assessment of the state of adverse processes in gynecological patients, using highly volatile compounds of an invasive biological test (cervical mucus), which makes it possible to assess the patient’s gynecological status in real time in a doctor’s office. A highly sensitive detector based on seven mass-sensitive piezoelectric sensors containing nanostructured electrode modifiers, having different selectivity to volatile biomolecules (alcohols, aldehydes, ketones, acids, amines) was used. Simple quantitative and qualitative parameters of a sensor array for a mixture of volatile compounds released by a bioassay are considered and substantiated. The boundaries of the quantitative parameters of the sensor array for ranking the samples into the groups “conditionally healthy,” “inflammation/infection,” and “remission” are considered. The ranges of normalized quantitative parameters of the array of the studied sensors, corresponding to the boundaries of unambiguous decision-making on the state of the bioassay and processes in the body, were identified. For the “conditionally healthy” group, the reliable estimate is in the range of up to 1%, for the “remission” group, it is 20–40%, and for the “inflammation/infection” group, it is more than 60%. A procedure for assessing the gynecological status of a person by volatile compounds of cervical mucus using an electronic nose was developed. The procedure was tested together with gynecologists in real conditions of appointment and medical examination of patients. The accuracy of ranking the samples into the groups “conditionally healthy,” “inflammation/infection,” and “remission” is 90%; the analysis time is 5–10 min. No internal calibration of the sensors is required; the reliable operation time of the array is at least 1 year; the performance of the procedure is 5 samples/h.

中文翻译：

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基于压电传感器的电子鼻在妇科检查挥发性化合物扫描中的应用

摘要

我们提出了一种快速评估妇科患者不良过程状态的方法，使用侵入性生物测试（宫颈粘液）的高挥发性化合物，这使得在医生办公室实时评估患者的妇科状态成为可能。使用基于七个质量敏感压电传感器的高灵敏度检测器，其中包含纳米结构电极改性剂，对挥发性生物分子（醇、醛、酮、酸、胺）具有不同的选择性。考虑并证实了用于生物测定释放的挥发性化合物混合物的传感器阵列的简单定量和定性参数。用于将样品分为“条件健康”、“炎症/感染、”和“缓解”。确定了所研究传感器阵列的归一化定量参数的范围，对应于对生物测定状态和体内过程的明确决策的边界。对于“条件健康”组，可靠估计在 1% 以内，对于“缓解”组，为 20-40%，对于“炎症/感染”组，超过 60 %。开发了一种使用电子鼻通过宫颈粘液的挥发性化合物评估人的妇科状况的程序。该程序与妇科医生一起在患者预约和体检的实际条件下进行了测试。将样本分为“条件健康”、“炎症/感染”和“缓解”组的准确率为90%；分析时间为 5-10 分钟。无需对传感器进行内部校准；阵列的可靠运行时间至少为1年；该程序的性能是 5 个样品/小时。