Antibiotic resistance is a serious problem facing the world; it is increasing every year due to over or misuse of antibiotics that led to developing new mechanisms of drug resistance by bacteria. In the present study Magneto-Liposomes (MLs) loaded with Erythromycin drug were designed; They were subjected to 5 and 15 mT Alternating Magnetic Field (AMF) at 100 KHz for 30 min of exposure to test the effect of exposure to the AMF on inducing the drug release rate beyond the resistance mechanism of bacteria. During exposure, the temperature of the sample was continuously recorded using IR thermometer. After exposure, the percentage of drug released was tested using UPLC-MS/MS method for every hour until 8 h then at 24 h post-exposure. Results showed an elevated temperature of 4 and 24°C in case of exposure the Erythromycin-encapsulated MLs to 5 and 15 mT respectively. Moreover, an increase in the percentage of Erythromycin release with a percentage of (0.83 ± 0.1) μg/mL and with (1.33 ± 4) × 10^–7 μg/mL for exposure to 5 and 15 mT respectively, with respect to (0.24 ± 0.06) μg/mL in the control group. Exposing Erythromycin-encapsulated ML to AMF accelerated the release rate due to mechanical actuation of the nanoparticles. These findings suggest that it is possible to trigger and control the drug release by merging the targeted drug delivery system with the nanotechnology and magnetic field. Upon increasing the intensity of the AMF, the release rate increased significantly.

抗生素耐药性是世界面临的严重问题；由于过度或滥用抗生素导致细菌产生耐药性的新机制，它每年都在增加。在本研究中，设计了装载红霉素药物的磁脂质体 (MLs)；他们在 100 KHz 的 5 和 15 mT 交变磁场 (AMF) 下暴露 30 分钟，以测试暴露于 AMF 对诱导超出细菌抵抗机制的药物释放速率的影响。在曝光期间，使用红外温度计连续记录样品的温度。暴露后，每小时使用 UPLC-MS/MS 方法测试药物释放的百分比，直到 8 小时，然后在暴露后 24 小时。结果显示，在将红霉素包封的 ML 分别暴露于 5 和 15 mT 的情况下，温度会升高 4°C 和 24°C。此外，红霉素释放百分比增加（0.83±0.1）μg/mL和（1.33±4）×10^–7 μg/mL 分别暴露于 5 和 15 mT，相对于对照组中的 (0.24 ± 0.06) μg/mL。由于纳米颗粒的机械驱动，将红霉素包封的 ML 暴露于 AMF 加速了释放速率。这些发现表明，通过将靶向给药系统与纳米技术和磁场相结合，可以触发和控制药物释放。随着 AMF 强度的增加，释放速率显着增加。