Purpose of Review

Recent technological advances have led to an increased ability to define the gene expression profile of the cardiac conduction system (CCS). Here, we review the most salient studies to emerge in recent years and discuss existing gaps in our knowledge as well as future areas of investigation.

Recent Findings

Molecular profiling of the CCS spans several decades. However, the advent of high-throughput sequencing strategies has allowed for the discovery of unique transcriptional programs of the many diverse CCS cell types.

Summary

The CCS, a diverse structure with significant inter- and intra-component cellular heterogeneity, is essential to the normal function of the heart. Progress in transcriptomic profiling has improved the resolution and depth of characterization of these unique and clinically relevant CCS cell types. Future studies leveraging this big data will play a crucial role in improving our understanding of CCS development and function as well as translating these findings into tangible translational tools for the improved detection, prevention, and treatment of cardiac arrhythmias.

中文翻译：

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心脏传导系统的分子分析：新时代的曙光

审查目的

最近的技术进步提高了定义心脏传导系统 (CCS) 基因表达谱的能力。在这里，我们回顾了近年来出现的最突出的研究，并讨论了我们知识中的现有差距以及未来的调查领域。

最近的发现

CCS 的分子分析跨越了几十年。然而，高通量测序策略的出现允许发现许多不同 CCS 细胞类型的独特转录程序。

概括

CCS 是一种具有显着组分间和组分内细胞异质性的多样化结构，对心脏的正常功能至关重要。转录组分析的进展提高了这些独特且临床相关的 CCS 细胞类型的分辨率和表征深度。利用这些大数据的未来研究将在提高我们对 CCS 发展和功能的理解以及将这些发现转化为有形的转化工具以改进心律失常的检测、预防和治疗方面发挥关键作用。