Abstract

Two monoclonal antibodies recognizing non-overlapping epitopes of the PRAME protein were injected into immunocompetent mice to study their influence on the growth of subcutaneous tumor nodes. The B16F10 murine melanoma line, either expressing human PRAME protein or bearing only a vector without PRAME gene, were used as transplants. Each of the antibodies showed the ability to suppress tumor growth of a PRAME-expressing tumour, but not a tumor without PRAME.

中文翻译：

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PRAME 蛋白单克隆抗体减缓表达 PRAME 的肿瘤的发展

摘要

将识别 PRAME 蛋白非重叠表位的两种单克隆抗体注射到免疫活性小鼠中，以研究它们对皮下肿瘤节点生长的影响。B16F10 鼠黑色素瘤系，要么表达人 PRAME 蛋白，要么只带有一个没有PRAME基因的载体，被用作移植物。每种抗体都显示出抑制表达 PRAME 的肿瘤的肿瘤生长的能力，但不能抑制没有 PRAME 的肿瘤。