Abstract
Two monoclonal antibodies recognizing non-overlapping epitopes of the PRAME protein were injected into immunocompetent mice to study their influence on the growth of subcutaneous tumor nodes. The B16F10 murine melanoma line, either expressing human PRAME protein or bearing only a vector without PRAME gene, were used as transplants. Each of the antibodies showed the ability to suppress tumor growth of a PRAME-expressing tumour, but not a tumor without PRAME.
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Funding
This study was supported by the Ministry of Science and Higher Education of the Russian Federation (Agreement no. 075-15-2019-1249 dated June 10, 2019), unique project identifier RFMEFI60418X0204).
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Statement on the welfare of animals. All experiments on animals were carried out in accordance with the requirements of the Commission for the Control of the Maintenance and Use of Animals of the FIBC RAS (Minutes no. 117 of February 18, 2020).
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Translated by M. Batrukova
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Solopova, O.N., Finashutina, Y.P., Kasatkina, N.N. et al. Monoclonal Antibodies to PRAME Protein Slow the Development of PRAME-Expressing Tumor. Dokl Biochem Biophys 498, 199–202 (2021). https://doi.org/10.1134/S1607672921030091
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DOI: https://doi.org/10.1134/S1607672921030091