Abstract

The combined effect of the irradiation with a proton pencil scanning beam (PBS) at a total dose of 80 Gy and neutron radiation at a dose of 5 Gy on the growth of solid Ehrlich ascites carcinoma (EAC) and the remote effects in tumor-bearing mice was studied. Combined irradiation of mice with neutrons before and after irradiation with PBS, as well as irradiation only with PBS, effectively suppressed the growth of solid EAC within 1 month. In terms of the frequency and severity of radiation-induced skin reactions of mice observed 15–40 days after therapy, neutron irradiation after the irradiation with PBS showed better values of these parameters as compared to only PBS; however, exposure to neutrons before PBS was more damaging as compared to the other two options. It was also shown that the tumor relapse rate in the groups of animals with combined irradiation was higher, and the total lifespan was lower than the group of mice irradiated with PBS alone.

中文翻译：

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中子和质子辐射对小鼠实性艾氏腹水癌生长的联合作用和远程效应

摘要

总剂量为 80 Gy 的质子笔扫描束 (PBS) 照射和 5 Gy 剂量的中子辐射对实体 Ehrlich 腹水癌 (EAC) 生长的综合影响和对荷瘤的远程影响小鼠进行了研究。PBS 照射前后中子联合照射小鼠，以及仅用 PBS 照射，在 1 个月内有效抑制了固体 EAC 的生长。就治疗后 15-40 天观察到的小鼠辐射引起的皮肤反应的频率和严重程度而言，PBS 照射后的中子照射显示这些参数的值比仅 PBS 更好；然而，与其他两种选择相比，在 PBS 之前暴露于中子更具破坏性。