In this work, new pyrazole derivatives were prepared by one-pot three-component reaction emloying symmetric and asymmetric 1,2-disulfonyl-hydrazines, cyclohexyl isocyanide, and dialkyl acetylenedicarboxylates. Reactions with asymmetric 1,2-disulfonylhydrazines led to two regioisomers, which were distinguished by density functional theory calculations and the major isomer attributed to the energically more stable one.

中文翻译：

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来自对称和不对称 1,2-二磺酰肼的高度官能化吡唑啉：实验和 DFT 观点的结合

在这项工作中，采用对称和不对称的 1,2-二磺酰肼、异氰环己基酯和二烷基乙炔二羧酸酯通过一锅三组分反应制备了新型吡唑衍生物。与不对称 1,2-二磺酰肼的反应产生两种区域异构体，通过密度泛函理论计算区分它们，主要异构体归因于能量更稳定的异构体。