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Highly functionalized pyrazolines from symmetric and asymmetric 1,2-disulfonylhydrazines: a combination of experimental and DFT perspectives

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Chemistry of Heterocyclic Compounds Aims and scope

In this work, new pyrazole derivatives were prepared by one-pot three-component reaction emloying symmetric and asymmetric 1,2-disulfonyl-hydrazines, cyclohexyl isocyanide, and dialkyl acetylenedicarboxylates. Reactions with asymmetric 1,2-disulfonylhydrazines led to two regioisomers, which were distinguished by density functional theory calculations and the major isomer attributed to the energically more stable one.

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Authors are grateful to the University of Mohaghegh Ardabili for the financial support and the laboratories of Tehran University and Tabriz University for the product analysis.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, 56199-11367, Iran

    Nasimeh Safari, Gholamhassan Imanzadeh, Roghayyeh Asgharzadeh, Seyyedeh Tahereh Hosseyni, Amir Nasser Shamkhali & Zahra Soltanzadeh

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  1. Nasimeh Safari
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  2. Gholamhassan Imanzadeh
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  3. Roghayyeh Asgharzadeh
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  4. Seyyedeh Tahereh Hosseyni
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  5. Amir Nasser Shamkhali
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  6. Zahra Soltanzadeh
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Correspondence to Gholamhassan Imanzadeh.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2021, 57(6), 640–645

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Safari, N., Imanzadeh, G., Asgharzadeh, R. et al. Highly functionalized pyrazolines from symmetric and asymmetric 1,2-disulfonylhydrazines: a combination of experimental and DFT perspectives. Chem Heterocycl Comp 57, 640–645 (2021). https://doi.org/10.1007/s10593-021-02962-y

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  • DOI: https://doi.org/10.1007/s10593-021-02962-y

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