It is controversial whether there is a different risk of recurrence between two histological subtypes in craniopharyngioma (CP) patients. Some reported that adamantinomatous craniopharyngioma (ACP) had a higher risk of recurrence than papillary craniopharyngioma (PCP), but others reported that there is no significant difference between them. So, we conducted this systematic review and meta-analysis to determine the association between the histological subtype of CP and the rate of recurrence. A comprehensive literature search was undertaken in PubMed, EMBASE, and Web of Science for all English articles published up to November 2020. Recurrence data stratified by ACP and PCP were extracted from studies meeting inclusion criteria. A pooled analysis of the association between the histological subtype of craniopharyngioma and rates of recurrence was performed. Thirteen articles containing 974 patients were included. When stratified by two pathological subtypes, the total recurrence rate of ACP was 26.0% and PCP was 14.1%, which showed ACP associated with a higher risk of tumor recurrence than PCP (odds ratio [OR] = 2.12, 95% confidence interval [CI] = 1.36, 3.30, P = 0.00). This is the first meta-analysis focusing on histological subtypes of CP. PCP associates with a lower risk of recurrence than ACP, indicating that ACP could act as one of recurrence risk factors for CP patients. Nevertheless, large sample size and well-designed multicenter studies in which the other clinical variables are controlled to determine the histological subtype of CP as an independent recurrence risk factor are needed.

颅咽管瘤 (CP) 患者的两种组织学亚型之间是否存在不同的复发风险存在争议。一些人报告说，金刚瘤颅咽管瘤（ACP）的复发风险高于乳头状颅咽管瘤（PCP），但也有人报告说两者之间没有显着差异。因此，我们进行了这项系统评价和荟萃分析，以确定 CP 的组织学亚型与复发率之间的关联。在 PubMed、EMBASE 和 Web of Science 中对截至 2020 年 11 月发表的所有英文文章进行了全面的文献检索。从符合纳入标准的研究中提取了按 ACP 和 PCP 分层的复发数据。对颅咽管瘤的组织学亚型与复发率之间的关联进行了汇总分析。包含 974 名患者的 13 篇文章被纳入。按两种病理亚型分层时，ACP 的总复发率为 26.0%，PCP 为 14.1%，这表明 ACP 的肿瘤复发风险高于 PCP（比值比 [OR] = 2.12，95% 置信区间 [CI ] = 1.36, 3.30,P  = 0.00)。这是第一个关注 CP 组织学亚型的荟萃分析。与 ACP 相比，PCP 的复发风险较低，表明 ACP 可能是 CP 患者的复发风险因素之一。然而，需要大样本量和精心设计的多中心研究，其中控制其他临床变量以确定 CP 的组织学亚型作为独立的复发风险因素。