Surfactant is one of the most important chemical entities in drug formulation which can bind with drug molecules. Herein, the binding interaction of ciprofloxacin hydrochloride (CFH) drug with two different surfactants (sodium dodecyl sulfate (SDS) and Triton X-100 (TX-100)) has been investigated through UV-Visible spectroscopic and cloud point measurement techniques at different conditions. The absorption spectrum of CFH was found to be dependent on presence of additives/temperature change. The binding constant (K_b) of CFH+SDS/CFH+TX-100 was found to be increased primarily, reached a maximum value and then decreased with the increase of temperature, except in water medium (pH=2.0) and 30% (v/v) methanol. The K_b values for CFH+SDS were found to be higher in the aqueous medium than almost all medium studied herein, while better binding was observed in the alcoholic medium in the case of the CFH+TX-100 system. The Gibbs free energy of binding (ΔG ^o_b ) for both CFH+SDS and CFH+TX-100 systems were attained negative in each case studied, inferring the spontaneous binding phenomenon. The cloud point (CP) value of CFH+TX-100 mixture was lessened in ZnSO₄·7H₂O solution and the CP values exhibited a gradual reduction through the upsurge of electrolyte concentration. The positive values of the Gibbs free energy of clouding indicated the nonspontaneous clouding phenomena. To disclose the interaction between drug and surfactant, other thermodynamic parameters, e.g., enthalpy (ΔH ^o_b ) and entropy (ΔS ^o_b ), different transfer energies as well as entropy-enthalpy compensation parameters of binding/clouding were evaluated and clarified with proper explanation.

表面活性剂是药物制剂中最重要的化学实体之一，可以与药物分子结合。在此，通过紫外-可见光谱和浊点测量技术在不同条件下研究了盐酸环丙沙​​星 (CFH) 药物与两种不同表面活性剂（十二烷基硫酸钠 (SDS) 和 Triton X-100 (TX-100)）的结合相互作用. 发现 CFH 的吸收光谱取决于添加剂的存在/温度变化。发现CFH+SDS/CFH+TX-100的结合常数（K _b）随着温度的升高首先增加，达到最大值然后减小，除了在水介质（pH = 2.0）和30％（ v/v) 甲醇。在K _b发现 CFH+SDS 在水性介质中的 CFH+SDS 值高于本文研究的几乎所有介质，而在 CFH+TX-100 系统的情况下，在醇介质中观察到更好的结合。CFH+SDS 和 CFH+TX-100 系统的吉布斯结合自由能 (ΔG ^o _b ) 在所研究的每种情况下都为负值，推断自发结合现象。CFH+TX-100混合物在ZnSO ₄ ·7H _{2 中}的浊点（CP）值降低 O 溶液和 CP 值随着电解质浓度的升高而逐渐降低。混浊吉布斯自由能的正值表示非自发混浊现象。为了揭示药物和表面活性剂之间的相互作用，评估并澄清了其他热力学参数，例如焓（ΔH ^o _b）和熵（ΔS ^o _b），不同的转移能以及结合/混浊的熵-焓补偿参数解释。