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Spectroscopic and cloud point studies of the interaction and thermodynamics of ciprofloxacin hydrochloride+surfactants mixture in different solvents: Effect of temperature and composition

  • Separation Technology, Thermodynamics
  • Published:
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Abstract

Surfactant is one of the most important chemical entities in drug formulation which can bind with drug molecules. Herein, the binding interaction of ciprofloxacin hydrochloride (CFH) drug with two different surfactants (sodium dodecyl sulfate (SDS) and Triton X-100 (TX-100)) has been investigated through UV-Visible spectroscopic and cloud point measurement techniques at different conditions. The absorption spectrum of CFH was found to be dependent on presence of additives/temperature change. The binding constant (Kb) of CFH+SDS/CFH+TX-100 was found to be increased primarily, reached a maximum value and then decreased with the increase of temperature, except in water medium (pH=2.0) and 30% (v/v) methanol. The Kb values for CFH+SDS were found to be higher in the aqueous medium than almost all medium studied herein, while better binding was observed in the alcoholic medium in the case of the CFH+TX-100 system. The Gibbs free energy of binding (ΔG ob ) for both CFH+SDS and CFH+TX-100 systems were attained negative in each case studied, inferring the spontaneous binding phenomenon. The cloud point (CP) value of CFH+TX-100 mixture was lessened in ZnSO4·7H2O solution and the CP values exhibited a gradual reduction through the upsurge of electrolyte concentration. The positive values of the Gibbs free energy of clouding indicated the nonspontaneous clouding phenomena. To disclose the interaction between drug and surfactant, other thermodynamic parameters, e.g., enthalpy (ΔH ob ) and entropy (ΔS ob ), different transfer energies as well as entropy-enthalpy compensation parameters of binding/clouding were evaluated and clarified with proper explanation.

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Abbreviations

CFH:

ciprofloxacin hydrochloride

SDS:

sodium dodecyl sulfate

TX-100:

Triton X-100

ZnSO4·7H2O:

zinc sulfate

MFP:

mass fractional purity

Kb :

binding constant

cmc:

critical micelle concentration

ΔG ob :

Gibbs free energy of binding

ΔH ob :

enthalpy of binding

ΔS ob :

entropy of binding

ΔG ob,tr :

free energy of transfer

ΔH ob,tr :

enthalpy of transfer

ΔS ob,tr :

entropy of transfer

ΔH o,*b :

intrinsic enthalpy

Tc :

compensation temperature

CP:

cloud point

ΔG 0c :

Gibbs free energy of clouding

ΔH 0c :

enthalpy of clouding

ΔS 0c :

entropy of clouding

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Acknowledgement

The authors extend their appreciation to the Deanship of Scientific Research at King Saud University for funding this work through research group no. RG-1441-461.

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Authors and Affiliations

  1. Department of Chemistry, Jahangirnagar University, Savar, Dhaka, 1342, Bangladesh

    Md. Anamul Hoque, Md. Mofaqkharur Rahman, Mohammed Abdullah Khan & Md. Ruhul Amin

  2. Department of Chemistry & Physics, Gono Bishwabidyalay, Savar, Dhaka, 1344, Bangladesh

    Shamim Mahbub & Md. Ruhul Amin

  3. Department of Chemistry, Hajee Mohammad Danesh Science & Technology University, Dinajpur, 5200, Bangladesh

    Mezbah Hossain

  4. Department of Pharmacognosy, College of Pharmacy, King Saud University, PO Box 2457, Riyadh, 11451, Saudi Arabia

    Ali S. Alqahtani, Mohammad Z. Ahmed & Omar M. Almarfadi

  5. Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia

    Mohammed S. Alqahtani

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  1. Md. Anamul Hoque
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  2. Md. Mofaqkharur Rahman
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11814_2021_786_MOESM1_ESM.pdf

Spectroscopic and cloud point studies of the interaction and thermodynamics of ciprofloxacin hydrochloride+surfactants mixture in different solvents: Effect of temperature and composition

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Hoque, M.A., Rahman, M.M., Mahbub, S. et al. Spectroscopic and cloud point studies of the interaction and thermodynamics of ciprofloxacin hydrochloride+surfactants mixture in different solvents: Effect of temperature and composition. Korean J. Chem. Eng. 38, 1487–1498 (2021). https://doi.org/10.1007/s11814-021-0786-4

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  • DOI: https://doi.org/10.1007/s11814-021-0786-4

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