Abstract

Differential effect of the neonatal proinflammatory stress (NPS) on the development of neuroinflammation in the hippocampus and induction of the depressive-like behavior in juvenile and adult male and female rats was studied. NPS induction by bacterial lipopolysaccharide in the neonatal period upregulated expression of the Il6 and Tnf mRNAs accompanied by the development of depressive-like behavior in the adult male rats. NPS increased expression of the mRNAs for fractalkine and its receptor in the ventral hippocampus of the juvenile male rats, but did not affect expression of mRNAs for the proinflammatory cytokines and soluble form of fractalkine. NPS downregulated expression of fractalkine mRNA in the dorsal hippocampus of juvenile males. No significant effects of NPS were found in the female rats. Therefore, the NPS induces long-term changes in the expression of neuroinflammation-associated genes in different regions of the hippocampus, which ultimately leads to the induction of neuroinflammation and development of depressive-like behavior in male rats.

中文翻译：

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新生儿促炎应激与大鼠海马神经炎症相关基因的表达

摘要

研究了新生儿促炎应激 (NPS) 对海马神经炎症发展和幼年和成年雄性和雌性大鼠抑郁样行为的不同影响。新生儿期细菌脂多糖诱导 NPS 上调Il6和Tnf 的表达mRNAs伴随成年雄​​性大鼠抑郁样行为的发展。NPS 增加了幼年雄性大鼠腹侧海马中 fractalkine 及其受体 mRNA 的表达，但不影响促炎细胞因子和可溶形式的 fractalkine mRNA 的表达。NPS 下调幼年雄性背海马中 fractalkine mRNA 的表达。在雌性大鼠中未发现 NPS 的显着影响。因此，NPS诱导海马不同区域神经炎症相关基因表达的长期变化，最终导致雄性大鼠神经炎症的诱导和抑郁样行为的发展。