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Analysis of anti-obesity and anti-diabetic effects of acacia bark-derived proanthocyanidins in type 2 diabetes model KKAy mice
Journal of Natural Medicines ( IF 2.5 ) Pub Date : 2021-06-13 , DOI: 10.1007/s11418-021-01537-7
Mayumi Kashiwada 1 , Saho Nakaishi 1 , Ayumi Usuda 1 , Yumi Miyahara 1 , Kenta Katsumoto 1 , Kyoko Katsura 1 , Izumi Terakado 1 , Makiko Jindo 1 , Shihori Nakajima 1 , Sosuke Ogawa 2 , Kiyoshi Sugiyama 3 , Wataru Ochiai 1
Affiliation  

The acacia bark extract derived from Acacia mearnsii De Wild is rich in proanthocyanidins, whose constituent units are robinetinidol, fisetinidol, catechin, and gallocatechin. In this study, we examined the effect of proanthocyanidins on obesity and diabetes using KKAy mice, a type 2 diabetes model. KKAy mice were fed either a low-fat diet, a high-fat diet, or a high-fat diet mixed with an acacia bark extract, a proanthocyanidins fraction, and other fraction for 7 weeks. Monitoring the changes in the body weight revealed that acacia bark extract and proanthocyanidins fraction could prevent excessive weight gain resulting from a high-fat diet. In addition, increases in the fasting blood glucose level due to high-fat diet intake were found to be suppressed by acacia bark extract and proanthocyanidins fraction. Furthermore, proanthocyanidins derived from acacia bark were found to increase the expression of adiponectin in white adipose tissue, which enhances the action of insulin. In addition, acacia bark-derived proanthocyanidins suppressed gluconeogenesis and fatty acid synthesis in the liver, as well as suppressing the decrease in energy production under pathological conditions in skeletal muscle. In addition, acacia bark-derived proanthocyanidins showed AMPK activation and DPP-4 inhibitory action. Therefore, it was suggested that acacia bark-derived proanthocyanidins lowered fasting blood glucose levels through the above mechanism. These results suggest that proanthocyanidins derived from acacia bark are the active ingredients of the anti-obesity and anti-diabetic effects of acacia bark extract.

Graphic abstract



中文翻译:

金合欢树皮原花青素对 2 型糖尿病模型 KKAy 小鼠的抗肥胖和抗糖尿病作用分析

来自金合欢的金合欢树皮提取物De Wild 含有丰富的原花青素,其组成单位是robinetinidol、fisetinidol、儿茶素和没食子儿茶素。在这项研究中,我们使用 KKAy 小鼠(一种 2 型糖尿病模型)检查了原花青素对肥胖和糖尿病的影响。KKAy 小鼠被喂食低脂肪饮食、高脂肪饮食或混合了金合欢树皮提取物、原花青素部分和其他部分的高脂肪饮食 7 周。监测体重的变化表明,金合欢树皮提取物和原花青素部分可以防止高脂肪饮食导致的体重过度增加。此外,金合欢树皮提取物和原花青素部分抑制了由于高脂肪饮食摄入引起的空腹血糖水平的升高。此外,发现来自金合欢树皮的原花青素可增加白色脂肪组织中脂联素的表达,从而增强胰岛素的作用。此外,金合欢树皮来源的原花青素抑制肝脏中的糖异生和脂肪酸合成,并抑制骨骼肌病理条件下能量产生的减少。此外,金合欢树皮来源的原花青素显示出 AMPK 活化和 DPP-4 抑制作用。因此,有人认为金合欢树皮来源的原花青素通过上述机制降低了空腹血糖水平。这些结果表明,来自金合欢树皮的原花青素是金合欢树皮提取物具有抗肥胖和抗糖尿病作用的活性成分。从而增强胰岛素的作用。此外,金合欢树皮来源的原花青素抑制肝脏中的糖异生和脂肪酸合成,并抑制骨骼肌病理条件下能量产生的减少。此外,金合欢树皮来源的原花青素显示出 AMPK 活化和 DPP-4 抑制作用。因此,有人认为金合欢树皮来源的原花青素通过上述机制降低了空腹血糖水平。这些结果表明,来自金合欢树皮的原花青素是金合欢树皮提取物具有抗肥胖和抗糖尿病作用的活性成分。从而增强胰岛素的作用。此外,金合欢树皮来源的原花青素抑制肝脏中的糖异生和脂肪酸合成,并抑制骨骼肌病理条件下能量产生的减少。此外,金合欢树皮来源的原花青素显示出 AMPK 活化和 DPP-4 抑制作用。因此,有人认为金合欢树皮来源的原花青素通过上述机制降低了空腹血糖水平。这些结果表明,来自金合欢树皮的原花青素是金合欢树皮提取物具有抗肥胖和抗糖尿病作用的活性成分。以及抑制骨骼肌病理条件下能量产生的减少。此外,金合欢树皮来源的原花青素显示出 AMPK 活化和 DPP-4 抑制作用。因此,有人认为金合欢树皮来源的原花青素通过上述机制降低了空腹血糖水平。这些结果表明,来自金合欢树皮的原花青素是金合欢树皮提取物具有抗肥胖和抗糖尿病作用的活性成分。以及抑制骨骼肌病理条件下能量产生的减少。此外,金合欢树皮来源的原花青素显示出 AMPK 活化和 DPP-4 抑制作用。因此,有人认为金合欢树皮来源的原花青素通过上述机制降低了空腹血糖水平。这些结果表明,来自金合欢树皮的原花青素是金合欢树皮提取物具有抗肥胖和抗糖尿病作用的活性成分。

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更新日期:2021-06-14
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