The cytotoxic activity of perfluoroalkyl imidazoindazoles and imidazobenzisoxazoles with respect to MCF-7 (human breast carcinoma) and HepG2 cell lines (human hepatocellular carcinoma) was studied. The imidazoindazoles exhibited significant cytotoxicity against MCF-7 and HepG2 cell lines. 2,6-bis(4-Fluorophenyl)-4,4-dimethyl-8-trifluoromethyl-3,4,5,6-tetrahydroimidazo[4,5-e]indazole displayed the most pronounced cytotoxic action. Regioisomeric imidazobenzisoxazoles inhibited extensively growth of HepG2 cells. The mechanism of cytotoxic action can be related to the induction of apoptosis as a result of disruption of the cell cycle, in particular, arrest of HepG2 cells in the G2 phase and MCF-7 cells in the G1 phase.

研究了全氟烷基咪唑并吲唑和咪唑苯并异恶唑对 MCF-7（人乳腺癌）和 HepG2 细胞系（人肝细胞癌）的细胞毒活性。咪唑并吲唑对 MCF-7 和 HepG2 细胞系表现出显着的细胞毒性。2,6-双(4-氟苯基)-4,4-二甲基-8-三氟甲基-3,4,5,6-四氢咪唑并[4,5- e ]吲唑表现出最显着的细胞毒作用。区域异构的咪唑并苯并异恶唑可广泛抑制 HepG2 细胞的生长。细胞毒作用的机制可能与细胞周期中断导致的细胞凋亡诱导有关，特别是 HepG2 细胞在 G2 期和 MCF-7 细胞在 G1 期的停滞。