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Recent advances in dearomatization of benzazoles, purines, and caffeine (microreview)
Chemistry of Heterocyclic Compounds ( IF 1.4 ) Pub Date : 2021-06-08 , DOI: 10.1007/s10593-021-02936-0
Liliang Huang , Huangdi Feng

Dearomatization reactions are well established in organic synthesis and other research fields usually leading to structurally diverse polycyclic molecules or complex heterocyclic frameworks. In this microreview, recent development of dearomative functionalization of benzazoles, purines, and caffeine via cycloaddition or addition reaction has been summarized. This will help researchers to find the potential scientific value of dearomatization reactions in drug discovery.



中文翻译:

苯并唑、嘌呤和咖啡因脱芳构化的最新进展(微评)

脱芳构化反应在有机合成和其他研究领域中已经很成熟,通常会导致结构多样化的多环分子或复杂的杂环骨架。在这篇微观评论中,总结了通过环加成或加成反应对苯并唑、嘌呤和咖啡因进行脱芳基官能化的最新进展。这将有助于研究人员发现脱芳构化反应在药物发现中的潜在科学价值。

更新日期:2021-06-08
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