The prevalence and functional characteristics of CrpP-like in Pseudomonas aeruginosa isolates from China,European Journal of Clinical Microbiology & Infectious Diseases

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The prevalence and functional characteristics of CrpP-like in Pseudomonas aeruginosa isolates from China
European Journal of Clinical Microbiology & Infectious Diseases ( IF 3.7 ) Pub Date : 2021-06-07 , DOI: 10.1007/s10096-021-04287-2
Ye Xu ₁ , Ying Zhang ₂ , Xiangkuo Zheng ₁ , Kaihang Yu ₂ , Yao Sun ₁ , Wenli Liao ₁ , Huaiyu Jia ₁ , Chunquan Xu ₁ , Tieli Zhou ₁ , Mo Shen ₁

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Modifying enzyme-CrpP and its variants reduced the MICs of fluoroquinolones in Pseudomonas aeruginosa. This study investigated the dissemination and functional characteristics of CrpP-like in P. aeruginosa from China. The positive rate of crpP-like genes in 228 P. aeruginosa was 25.4% (58/228), and 6 new crpP-like genes were determined. Transformation experiments showed that CrpP-like had a low effect on CIP and LEV susceptibility. The genetic of crpP-positive was diverse. Furthermore, the mean expression level of crpP was no statistical difference between fluoroquinolone-susceptible and -resistant group (P > 0.05). CrpP-like may not play a significant role in fluoroquinolone resistance in P. aeruginosa.

更新日期：2021-06-07

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