Abstract

The morphological features of human constitution, which are most often considered in regard to gene polymorphism, are indicators of the total fat deposition, since excess body weight and obesity contribute to an increased risk of developing many chronic diseases. Purpose. The purpose of this study is to search for possible associations between COMT gene rs4680 polymorphism and the morphological and functional characteristics of students in Russia and Transnistria. Materials and methods. The genotyping data (for the COMT gene) and complex anthropological examination (18 morphological and functional indicators) of 451 persons aged 16–23 years served as material for the study. Results. The study of the allele distribution in the surveyed sample of males and females showed the predominance of the G allele over the A allele (0.533 and 0.467, respectively), which is consistent with the data of other researchers obtained in samples of Russian residents of Novosibirsk and Americans of European descent. According to the results of a multistage statistical analysis of anthropogenetic data, it was revealed that young males and females who carry at least one A allele are not prone to a decreased metabolic rate and increased body weight compared with those with the homozygous G/G genotype. In turn, carriers of the G/G genotype are characterized by a decline in physical development: they have a lower proportion of the musculoskeletal component of body composition and a low rate of metabolic processes with an increased total body weight compared with individuals with the genotype A/A or A/G. Conclusions. Statistically significant associations of COMT gene rs4680 polymorphism with the characteristics of the body composition of young males and females were revealed, which confirms the data of other authors on the predisposition of carriers of the G/G genotype to obesity and type 2 diabetes mellitus, as well as to the consumption of high fat food.

中文翻译：

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儿茶酚-O-甲基转移酶基因 (COMT) 多态性与俄罗斯和德涅斯特河左岸学生形态功能指标的关联

摘要

人类体质的形态特征（最常被考虑与基因多态性有关）是总脂肪沉积的指标，因为超重和肥胖会增加患许多慢性疾病的风险。目的。本研究的目的是寻找COMT基因 rs4680 多态性与俄罗斯和德涅斯特河沿岸学生的形态和功能特征之间可能存在的关联。材料和方法。451 名 16-23 岁人群的基因分型数据（COMT基因）和复杂的人类学检查（18 个形态和功能指标）作为研究材料。结果。对男性和女性调查样本中等位基因分布的研究表明，G等位基因优于A等位基因（分别为0.533和0.467），这与其他研究人员在新西伯利亚俄罗斯居民样本中获得的数据一致和欧洲血统的美国人。根据人类遗传学数据的多阶段统计分析结果，发现携带至少一个A等位基因的年轻男性和女性与纯合G/G基因型的人相比，不易出现代谢率下降和体重增加的情况。 . 反过来，G/G 基因型携带者的特点是身体发育下降：结论。揭示了COMT基因 rs4680 多态性与年轻男性和女性身体成分特征的统计学显着关联，这证实了其他作者关于 G/G 基因型携带者易患肥胖和 2 型糖尿病的数据，如以及高脂肪食物的消耗。