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Associations of Catechol-O-Methyl Transferase Gene (COMT) Polymorphism with Morphofunctional Indicators in Russian and Transnistrian Students

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Abstract

The morphological features of human constitution, which are most often considered in regard to gene polymorphism, are indicators of the total fat deposition, since excess body weight and obesity contribute to an increased risk of developing many chronic diseases. Purpose. The purpose of this study is to search for possible associations between COMT gene rs4680 polymorphism and the morphological and functional characteristics of students in Russia and Transnistria. Materials and methods. The genotyping data (for the COMT gene) and complex anthropological examination (18 morphological and functional indicators) of 451 persons aged 16–23 years served as material for the study. Results. The study of the allele distribution in the surveyed sample of males and females showed the predominance of the G allele over the A allele (0.533 and 0.467, respectively), which is consistent with the data of other researchers obtained in samples of Russian residents of Novosibirsk and Americans of European descent. According to the results of a multistage statistical analysis of anthropogenetic data, it was revealed that young males and females who carry at least one A allele are not prone to a decreased metabolic rate and increased body weight compared with those with the homozygous G/G genotype. In turn, carriers of the G/G genotype are characterized by a decline in physical development: they have a lower proportion of the musculoskeletal component of body composition and a low rate of metabolic processes with an increased total body weight compared with individuals with the genotype A/A or A/G. Conclusions. Statistically significant associations of COMT gene rs4680 polymorphism with the characteristics of the body composition of young males and females were revealed, which confirms the data of other authors on the predisposition of carriers of the G/G genotype to obesity and type 2 diabetes mellitus, as well as to the consumption of high fat food.

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Funding

The study was supported by a grant from the Russian Foundation for Basic Research, project no. 18-09-00290 “Biological and Social Factors of Microevolutionary Changes in Morphofunctional Status and Sexual Dimorphism Level in Populations of the Modern people” and by the Program “Postgenomic Technologies and Promising Solutions in Biomedicine.”

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Authors and Affiliations

  1. Department of Biology, Moscow State University, 119991, Moscow, Russia

    A. A. Vasileva & M. A. Negasheva

  2. Institute of Gene Biology, Russian Academy of Sciences, 119334, Moscow, Russia

    V. A. Vasilyev

  3. Medical Department, Shevchenko Transnistria State University, 3300, Tiraspol, Republic of Moldova

    R. V. Okushko

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  1. A. A. Vasileva
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  3. R. V. Okushko
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Correspondence to A. A. Vasileva.

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Statement of compliance with standards of research involving humans as subjects. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants involved in the study.

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Translated by D. Novikova

ADDITIONAL INFORMATION

Vasileva A.A. – https://orcid.org/0000-0002-8025-8444; e-mail: vasileva@mail.bio.msu.ru

Vasilyev V.A. – https://orcid.org/0000-0003-2786-3327; e-mail: shunka@mail.ru

Okushko R.V. – https://orcid.org/0000-0002-4190-778X; e-mail: rovlok@mail.ru

Negasheva M.A. – https://orcid.org/0000-0002-7572-4316; e-mail: negasheva@mail.ru

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Vasileva, A.A., Vasilyev, V.A., Okushko, R.V. et al. Associations of Catechol-O-Methyl Transferase Gene (COMT) Polymorphism with Morphofunctional Indicators in Russian and Transnistrian Students. Mol. Genet. Microbiol. Virol. 36, 39–45 (2021). https://doi.org/10.3103/S0891416821010080

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