Endothelial dysfunction is considered as the main hallmark of Preeclampsia (PE). Despite the unknown pathogenesis of PE, different possible causes have been suggested in various studies. In this review, we first studied the Leukemia inhibitory factor (LIF) role in the related pathways to the PE pathogenesis, such as inflammation, endothelial dysfunction and hypertension. LIF can increase the expression of ICAM-1 and VCAM-1 via the JAK/STAT3 pathway, thereby inducing inflammatory responses and endothelial dysfunction. It can also be involved in the vascular vasoconstriction and hypertension by reducing the nitric oxide (NO) synthesis. Identifying the link between LIF and pathways associated with PE pathogenesis could be effective to achieve an effective PE treatment in the future.

内皮功能障碍被认为是先兆子痫（PE）的主要标志。尽管 PE 的发病机制未知，但在各种研究中提出了不同的可能原因。在这篇综述中，我们首先研究了白血病抑制因子（LIF）在炎症、内皮功能障碍和高血压等 PE 发病机制中的作用。LIF 可通过 JAK/STAT3 通路增加 ICAM-1 和 VCAM-1 的表达，从而诱导炎症反应和内皮功能障碍。它还可以通过减少一氧化氮 (NO) 的合成而参与血管收缩和高血压。确定 LIF 和与 PE 发病机制相关的途径之间的联系可能有助于在未来实现有效的 PE 治疗。