Mesenchymal stem cells from the adipose tissue (AT MSC) and the bone marrow (BM MSC) stimulated migration of melanoma B16 cells, while mammary adenocarcinoma Ca755 cells stimulated migration of mesenchymal stem cells. Mesenchymal stem cells retained these properties at late terms after γ-irradiation in vitro. Tumors that developed after injection of Ca755 cells alone and in combinations with BM MSC or AT MSC had similar histological structure corresponding to breast adenocarcinoma. Only AT MSC stimulated tumor growth, which was determined by more intensive secretion of factors stimulating proliferation of tumor cells, including chemokine CCL2. The use of AT MSC in regenerative medicine requires careful monitoring of the absence of tumors in patients.

来自脂肪组织 (AT MSC) 和骨髓 (BM MSC) 的间充质干细胞刺激黑色素瘤 B16 细胞的迁移，而乳腺腺癌 Ca755 细胞刺激间充质干细胞的迁移。间充质干细胞在体外γ-照射后保留了这些特性。单独注射 Ca755 细胞以及与 BM MSC 或 AT MSC 联合注射后形成的肿瘤具有与乳腺癌相似的组织学结构。只有 AT MSC 刺激肿瘤生长，这是由刺激肿瘤细胞增殖的因子（包括趋化因子 CCL2）的更密集分泌决定的。在再生医学中使用 AT MSC 需要仔细监测患者是否存在肿瘤。