Mesenchymal stem cells from the adipose tissue (AT MSC) and the bone marrow (BM MSC) stimulated migration of melanoma B16 cells, while mammary adenocarcinoma Ca755 cells stimulated migration of mesenchymal stem cells. Mesenchymal stem cells retained these properties at late terms after γ-irradiation in vitro. Tumors that developed after injection of Ca755 cells alone and in combinations with BM MSC or AT MSC had similar histological structure corresponding to breast adenocarcinoma. Only AT MSC stimulated tumor growth, which was determined by more intensive secretion of factors stimulating proliferation of tumor cells, including chemokine CCL2. The use of AT MSC in regenerative medicine requires careful monitoring of the absence of tumors in patients.
Similar content being viewed by others
References
Semochkina YuP, Rodina AV, Moskaleva EYu, Zhorova ES, Saprykin VP, Arzumanov SS, Safronov VV. Malignant transformation of mesenchymal stem cells from different mouse tissues after mixed gamma-neutron irradiation in vitro. Med. Rad. Radiats. Bezopasnost. 2019;64(1):5-14. https://doi.org/10.12737/article_5c55fb17a02054.31513592. Russian.
Atiya H, Frisbie L, Pressimone C, Coffman L. Mesenchymal stem cells in the tumor microenvironment. Adv. Exp. Med. Biol. 2020;1234:31-42. https://doi.org/10.1007/978-3-030-37184-5_3
Azenshtein E, Luboshits G, Shina S, Neumark E, Shahbazian D, Weil M, Wigler N, Keydar I, Ben-Baruch A. The CC chemokine RANTES in breast carcinoma progression: regulation of expression and potential mechanisms of promalignant activity. Cancer Res. 2002;62(4):1093-1102.
Boomsma RA, Geenen DL. Mesenchymal stem cells secrete multiple cytokines that promote angiogenesis and have contrasting effects on chemotaxis and apoptosis. PloS One. 2012;7(4):e35685. https://doi.org/10.1371/journal.pone.0035685
Dwyer RM, Potter-Beirne SM, Harrington KA, Lowery AJ, Hennessy E, Murphy JM, Barry FP, O’Brien T, Kerin MJ. Monocyte chemotactic protein-1 secreted by primary breast tumors stimulates migration of mesenchymal stem cells. Clin. Cancer. Res. 2007;13(17):5020-5027. https://doi.org/10.1158/1078-0432.CCR-07-0731
Fitzsimmons REB, Mazurek MS, Soos A, Simmons CA. Mesenchymal stromal/stem cells in regenerative medicine and tissue engineering. Stem Cells Int. 2018;2018:8031718. https://doi.org/10.1155/2018/8031718
François S, Bensidhoum M, Mouiseddine M, Mazurier C, Allenet B, Semont A, Frick J, Saché A, Bouchet S, Thierry D, Gourmelon P, Gorin NC, Chapel A. Local irradiation not only induces homing of human mesenchymal stem cells at exposed sites but promotes their widespread engraftment to multiple organs: a study of their quantitative distribution after irradiation damage. Stem Cells. 2006;24(4):1020-1029. https://doi.org/10.1634/stemcells.2005-0260
Ghaffari-Nazari Н. The known molecules involved in MSC homing and migration. J. Stem Cell Res. Med. 2018;3(1):1-4. https://doi.org/10.15761/JSCRM.1000127
Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW, Richardson AL, Polyak K, Tubo R, Weinberg RA. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature. 2007;449:557-563. https://doi.org/10.1038/nature06188
Kidd S, Spaeth E, Watson K, Burks J, Lu H, Klopp A, Andreeff M, Marini FC. Origins of the tumor microenvironment: quantitative assessment of adipose-derived and bone marrowderived stroma. PloS One. 2012;7(2):e30563. https://doi.org/10.1371/journal.pone.0030563
Leibacher J, Henschler R. Biodistribution, migration and homing of systemically applied mesenchymal stem/stromal cells. Stem Cell Res. Ther. 2016;7:7. https://doi.org/10.1186/s13287-015-0271-2
Mi Z, Bhattacharya SD, Kim VM, Guo H, Talbot LJ, Kuo PC. Osteopontin promotes CCL5-mesenchymal stromal cell-mediated breast cancer metastasis. Carcinogenesis 2011;32(4):477-487. https://doi.org/10.1093/carcin/bgr009
Morein D, Erlichman N, Ben-Baruch A. Beyond cell motility: the expanding roles of chemokines and their receptors in malignancy. Front. Immunol. 2020;11:952. https://doi.org/10.3389/fimmu.2020.00952
Moskaleva EY, Semochkina YP, Shuvatova VG, Rodina AV, Krasheninnikova AA. Mesenchymal stem cells from mouse adipose tissue stimulate tumor growth. Bull. Exp. Biol. Med. 2019;167(1):145-149. https://doi.org/10.1007/s10517-019-04479-z
Quante M, Tu SP, Tomita H, Gonda T, Wang SS, Takashi S, Baik GH, Shibata W, Diprete B, Betz KS, Friedman R, Varro A, Tycko B, Wang TC. Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth. Cancer Cell. 2011;19(2):257-272. https://doi.org/10.1016/j.ccr.2011.01.020
Rahmatizadeh F, Gholizadeh-Ghaleh Aziz S, Khodadadi K, Lale Ataei M, Ebrahimie E, Soleimani Rad J, Pashaiasl M. Bidirectional and opposite effects of naïve mesenchymal stem cells on tumor growth and progression. Adv. Pharm. Bull. 2019;9(4):539-558. https://doi.org/10.15171/apb.2019.063
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 1, pp. 38-46, March, 2021
Rights and permissions
About this article
Cite this article
Moskaleva, E.Y., Zhorova, E.S., Semochkina, Y.P. et al. Mechanisms of Stimulation of the Growth of Mouse Mammary Adenocarcinoma by Mesenchymal Stem Cells. Bull Exp Biol Med 171, 141–149 (2021). https://doi.org/10.1007/s10517-021-05186-4
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-021-05186-4