Objectives Sclerostin is an important regulator of bone mass involving the Wnt/β-catenin signalling pathway. Relatively few studies have investigated the relationships of circulating sclerostin levels with adiposity-related and muscle-related biochemical factors in individuals with increased energy metabolism. The aim of this study was to investigate the associations of circulating sclerostin with adipokines, myokines, osteokines and body composition values in lean adolescent females with increased physical activity. Methods A total of 73 adolescent females who were physically active and aged 14–18 years old participated in the study. Sclerostin, leptin, resistin, tumour necrosis factor (TNF)-α, interleukin (IL)-6, irisin, osteocalcin, C-terminal telopeptide of type I collagen (CTx), insulin-like growth factor (IGF)-1 and insulin were obtained from fasting blood samples. Body composition was measured by dual-energy X-ray absorptiometry (DXA) and analyzed for body fat mass, lean body mass, bone mineral content and muscle mass. Results Serum sclerostin (117.9 ± 60.3 pg/mL) was correlated with age, age at menarche, body fat, muscle mass, training activity, leptin, TNF-α, irisin, osteocalcin, CTx and IGF-1. Multivariate linear regression analysis demonstrated that fat mass ( β = 0.434; p = 0.001), leptin ( β = −0.308; p = 0.015), irisin ( β = 0.227; p = 0.024) and CTx ( β = 0.290; p = 0.031) were the most important predictors of serum sclerostin concentration. Conclusions Bone-derived sclerostin is associated with specific adipokine, myokine and osteokine values in lean adolescent females with increased physical activity. These results suggest that the interactions between bone, adipose and muscle tissues could also be associated with circulating sclerostin concentrations.

中文翻译：

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血清硬化素浓度与体力活动增加的瘦青春期女性的特定脂肪、肌肉和骨组织标志物相关

目的 硬化蛋白是骨量的重要调节剂，涉及 Wnt/β-catenin 信号通路。在能量代谢增加的个体中，研究循环硬化蛋白水平与肥胖相关和肌肉相关生化因素之间的关系的研究相对较少。本研究的目的是调查循环硬化素与脂肪因子、肌肉因子、骨因子和体力活动增加的瘦青春期女性的身体成分值之间的关联。方法 73 名年龄在 14-18 岁之间、身体活跃的青春期女性参加了研究。硬化素、瘦素、抵抗素、肿瘤坏死因子 (TNF)-α、白细胞介素 (IL)-6、鸢尾素、骨钙素、I 型胶原的 C 端端肽 (CTx)、胰岛素样生长因子 (IGF)-1 和胰岛素来自空腹血样。通过双能 X 射线吸收仪 (DXA) 测量身体成分，并分析身体脂肪量、瘦体重、骨矿物质含量和肌肉质量。结果 血清硬化素 (117.9 ± 60.3 pg/mL) 与年龄、初潮年龄、体脂、肌肉质量、训练活动、瘦素、TNF-α、鸢尾素、骨钙素、CTx 和 IGF-1 相关。多元线性回归分析表明脂肪量 (β = 0.434; p = 0.001)、瘦素 (β = -0.308; p = 0.015)、鸢尾素 (β = 0.227; p = 0.024) 和 CTx (β = 0.290; p = 0.31) ) 是血清硬化素浓度的最重要预测因子。结论骨源性硬化蛋白与体力活动增加的瘦青春期女性的特定脂肪因子、肌因子和骨因子值相关。